158093-66-4

Upstream product

• 1027722-02-6 N-(4-Bromo-phenyl)-2-phenylmethanesulfinyl-nicotinamide 
• 38521-46-9 3-carboxy-2-mercaptopyridine 
• 1026589-74-1 2-Benzylsulfanyl-N-(4-bromo-phenyl)-nicotinamide 
• 112811-90-2 2-benzylsulfanylnicotinic acid 
• 156896-55-8 2-chlorothio-3-pyridinecarbonyl chloride 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 174468-83-8 2-(4-Bromo-phenyl)-1-oxo-1,2-dihydro-1λ⁴-isothiazolo[5,4-b]pyridin-3-one 

Relevant academic research and scientific papers

SYNTHESIS OF 2-SUBSTITUTED ISOTHIAZOLOPYRIDIN-3(2H)-ONE 1,1-DIOXIDES

The Isothiazolopyridin-3(2H)-one 1,1-dioxides (3a-g) were prepared from the corresponding isothiazolopyridin-3(2H)-ones (1a-g) by means of an oxidation with oxone (KHSO5) and sodium hypochlorite (NaOCl) in two steps.The influen

Heteroaryl-Fused 2-Phenylisothiazolone Inhibitors of Cartilage Breakdown

The synthesis, biological evaluation, and structure-activity relationships of a series of N-phenyl heteroaryl-fused isothiazolones are described.These isothiazolones have been shown to exhibit potent, dose-dependent inhibition of IL-1β-induced breakdown of proteoglycan in a cartilage organ culture assay.This effect is likely due to inhibition of MMP activation and a consequent reduction in MMP activity following IL-1β stimulation.Thus these compounds potentially represent simple, non-peptidic disease-modifying agents for the treatment of arthritic diseases.To examine the effects of structure on in vitro activity, three general features of the molecules were varied, substituents on the pendant N-phenyl group, the position of ring fusion to the isothiazolone, and substituents on the fused ring peri to the isothiazolone sulfur.