158119-63-2Relevant academic research and scientific papers
Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel
Brouillette,Jestkov,Brown,Akhtar,DeLorey,Brown
, p. 3289 - 3293 (1994)
The anticonvulsant activity of diphenylhydantoin (DPH or phenytoin) is consistent with its actions on the neuronal voltage-dependent sodium channel. To further elucidate the binding requirements for this site, we synthesized several hydantoin analogs and
