Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel

DOI: 10.1021/jm00046a013

Source and publish data:

Journal of Medicinal Chemistry p. 3289 - 3293 (1994)

Update date:2022-09-26

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Authors:

Brouillette

Jestkov Jestkov

Brown Brown

Akhtar Akhtar

DeLorey DeLorey

Brown Brown

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Article abstract of DOI:10.1021/jm00046a013

The anticonvulsant activity of diphenylhydantoin (DPH or phenytoin) is consistent with its actions on the neuronal voltage-dependent sodium channel. To further elucidate the binding requirements for this site, we synthesized several hydantoin analogs and

Full text of DOI:10.1021/jm00046a013

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