Journal of Medicinal Chemistry p. 3289 - 3293 (1994)
Update date:2022-09-26
Topics:
Brouillette
Jestkov
Brown
Akhtar
DeLorey
Brown
The anticonvulsant activity of diphenylhydantoin (DPH or phenytoin) is consistent with its actions on the neuronal voltage-dependent sodium channel. To further elucidate the binding requirements for this site, we synthesized several hydantoin analogs and
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