15812-40-5Relevant academic research and scientific papers
Palladium-Catalyzed highly diastereoselective oxidative cascade cyclization reactions
Yip, Kai-Tai,Zhu, Nian-Yong,Yang, Dan
supporting information; experimental part, p. 1911 - 1914 (2009/09/25)
Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)2/isoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr> 24:1).
