15817-28-4

Upstream product

• 7500-66-5 (1-bromocyclohexyl)(phenyl)methanone 
• 124-41-4 sodium methylate 
• 1135-71-3 (1-chlorocyclohexyl)(phenyl)methanone 
• 138723-84-9 2,2-pentamethylene-5-methoxy-5-phenyl-1,3,4-Δ³-oxadiazoline 
• 24214-79-7 cyclohexanone benzoylhydrazone 

Downstream Products

• 102168-37-6 1-(α-Methoxy-benzhydryl)-cyclohexanol 
• 7500-67-6 (1-benzoyloxy-cyclohexyl)-phenyl ketone 
• 947-19-3 1-hydroxycyclohexyl phenyl ketone 
• 6976-76-7 2-methoxy-2-phenyl-cycloheptanone 
• 843-51-6 1-[(2-chloro-ethoxy)-methoxy-phenyl-methyl]-cyclohexanol 
• 41848-75-3 phenyl-(1-phenyl-cyclohexyl)-ketone 
• 854-50-2 1-[methoxy-(2-morpholin-4-yl-ethoxy)-phenyl-methyl]-cyclohexanol 
• 839-13-4 (1-hydroxy-cyclohexyl)-phenyl ketone-dimethylacetal 

Relevant academic research and scientific papers

Electrooxidative Cyclization of N-Acylhydrazones of Aldehydes and Ketones to Δ3-1,3,4-Oxadiazolines and 1,3,4-Oxadiazoles

The electrolytic oxidation of ketone N-acylhydrazones (1) in methanolic sodium acetate induced their intramolecular cyclization to the corresponding 2-methoxy-Δ3-1,3,4-oxadiazolines 3.The thermal stability of a given oxadiazoline and what products were formed by its thermal decomposition was found to depend on the natures of the substituents at C-2.Thus, 2-methoxy-2-phenyloxadiazolines preferentially yielded oxiranes 5, whereas 2-alkyl-2-methoxyoxadiazolines preferentially gave enol ethers 6. 2,2-Dimethoxyoxadiazolines decomposed to the parent ketones and many unidentified products.The electrolytic oxidation of aldehyde N-acylhydrazones 2 gave 2,5-disubstituted 1,3,4-oxadiazoles 4.The oxidative cyclization of the N-benzoylhydrazones of aliphatic aldehydes gave especially high yields of the corresponding heterocycles.