158176-60-4Relevant academic research and scientific papers
METHOD FOR PRODUCING SALTS OF TOLPERISONE
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Page/Page column 6-9, (2008/06/13)
The invention relates to a method for producing an addition salt of 2,4'-dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of formula (I). According to the invention, 4-methylpropiophenone is reacted with piperidine hydrochloride and 1,2-dioxolane in the presence of an acid serving as a catalyst, and the tolperisone obtained in the form of an acid addition salt is separated by filtering after the reaction mixture has cooled down.
