1581780-54-2

Upstream product

• 1581780-53-1 8-bromo-5,6-dimethyl-3-thia-1,4,7,8 a-tetraaza-as-indacene 
• 351422-73-6 (3-(aminocarbonyl)phenyl)boronic acid 
• 1581780-51-9 5,6-dimethyl-3-thia-1,4,7,8 a-tetraaza-as-indacene 
• 1581780-52-0 N-(4-(4-methyl-1H-imidazol-1-yl)thiazol-5-yl)acetamide 
• 533886-05-4 N-(2,4-dibromothiazol-5-yl)acetamide 
• 408507-23-3 N-(thiazol-5-yl)acetamide 

Relevant academic research and scientific papers

Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors

Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribu

NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A

The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. where in formula I the variables X, Y, Q1, Q2 have the following meanings: X is C-R