158179-36-3

Basic information

• Product Name: 4-<3-(2,4-dimethoxyphenyl)-1-oxo-2-propenyl>-3-phenylsydnone
• Synonyms: 4-<3-(2,4-dimethoxyphenyl)-1-oxo-2-propenyl>-3-phenylsydnone
• CAS NO: 158179-36-3
• Molecular Weight: 352.346
• Mol File: 158179-36-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-<3-(2,4-dimethoxyphenyl)-1-oxo-2-propenyl>-3-phenylsydnone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-<3-(2,4-dimethoxyphenyl)-1-oxo-2-propenyl>-3-phenylsydnone(158179-36-3)
• EPA Substance Registry System: 4-<3-(2,4-dimethoxyphenyl)-1-oxo-2-propenyl>-3-phenylsydnone(158179-36-3)

Safety Data

• Hazardous Substances Data: 158179-36-3(Hazardous Substances Data)

Upstream product

• 6415-68-5 N-nitroso-N-phenylglycine 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 13973-33-6 4-acetyl-3-phenylsydnone 

Relevant articles and documents

Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4- [1-oxo-(3-substituted aryl)-2-propenyl]-3-phenylsydnones and of 3-[4-[3- (substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones

Two series of styrylcarbonyl 3-phenylsydnone derivatives, 4-[1-oxo-(3- substituted aryl)-2-propenyl]-3-phenylsydnones (series I, 1-21) and 3-[4-[3- (substituted aryl)-1-oxo-2-propenyl]phenyl]sydnones (series II, 22-40), were synthesized and evaluated pharmacologically at a dose of 100 mg/kg po. Eleven compounds in series I plus one in series II and six in series I plus seven in series II were active in the carrageenan-induced edema and acetic acid- induced writhing assays, respectively. Compound 35 in the latter assay showed activity somewhat similar to that of the positive control drug, aspirin, administered at the same dosage. Compounds 11, 17, and 23 showed activity in both assays, and 23 also was active in the adjuvant-induced arthritis assay.