13973-33-6Relevant academic research and scientific papers
Metal triflate-catalyzed friedel-crafts acetylation of 3-phenylsydnone
Balaguer, Amanda,Selhorst, Ryan,Turnbull, Kenneth
, p. 1626 - 1632 (2013)
Friedel-Crafts acetylation at the 4-position of 3-phenylsydnone (1) was achieved via thermal heating overnight in moderate to good yields by employing various metal triflate catalysts (5-20 mol%), lithium perchlorate (0-20 mol%), and acetic anhydride (4 e
Synthesis of aminopyrazoles from sydnones and ynamides
Wezeman,Comas-Barceló,Nieger,Harrity,Br?se
supporting information, p. 1575 - 1579 (2017/02/23)
Aminopyrazoles are prepared from readily accessible sydnones and sulfonyl ynamides using either a copper-mediated sydnone alkyne cycloaddition (CuSAC) or in situ generated strained cyclic ynamides.
Pyridine-catalyzed synthesis of quinoxalines as anticancer and anti-tubercular agents
Kamble, Atulkumar A.,Kamble, Ravindra R.,Kumbar, Mahadev N.,Tegginamath, Gireesh
, p. 1163 - 1174 (2016/07/06)
Quinoxaline derivatized with coumarin viz., 3a–f and with sydnones viz., 7a–0 were synthesized using pyridine as catalyst. Among the coumarin derivatives, 3a and 3b have been screened for anticancer activity against 60 human cancer cell lines at NIH (USA)
1,3-Dipolar cycloaddition between acetylenic dipolarophiles and sydnone-N-ylides as bis(1,3-dipoles)
Albota, Florin,Dr?ghici, Constantin,Caira, Mino R.,Dumitrascu, Florea
, p. 9095 - 9100 (2015/11/09)
1,3-Dipolar cycloaddition reaction of sydnone-N-ylides, as model bis(1,3-dipoles), with acetylenic dipolarophiles in 1,2-epoxybutane under reflux gave exclusively pyrroloazines containing a sydnone moiety that resulted by preferred reaction of the N-ylide
Bismuth triflate-catalyzed friedel-crafts acylations of sydnones
Mahoney, Jennifer,Turnbull, Kenneth,Cubberley, Mark
, p. 3220 - 3229 (2012/11/07)
Friedel-Crafts acylations of various 3-arylsydnones at the C4 position have been achieved in good yields using 4 equivalents of an alkyl anhydride and 25mol% each of bismuth triflate and lithium perchlorate in anhydrous acetonitrile at 95C. Acylations app
Synthesis of 2 H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes
Fang, Yuesi,Wu, Chunrui,Larock, Richard C.,Shi, Feng
, p. 8840 - 8851 (2012/01/02)
A rapid and efficient synthesis of 2H-indazoles has been developed using a [3 + 2] dipolar cycloaddition of sydnones and arynes. A series of 2H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed coupl
N-Bromosuccinimide (NBS) as Promoter for Acylation of Sydnones in the Presence of Acetic Anhydride under Neutral Conditions
Ghasemnejad-Bosra, Hassan,Haghdadi, Mina,Gholampour-Azizi, Issa
, p. 391 - 395 (2008/09/20)
Various 4 - acetyl sydnones (2) can be prepared by reaction of the corresponding 3-aryl sydnones (1) with acetic anhydride at ~110 °C promoted by N-Bromosuccinimide (NBS) as an effective reagent for acylation of sydnones under neutral conditions in satisf
Synthesis and biological study of some novel 4-[5-(4,6-disubstituted-2- thiomethylpyrimidyl)-4'-amino-1,2,4- triazol-3'-yl] thioacetyl-3-arylsydnones
Kalluraya, Balakrishna,Lingappa,Nooji, Satheesh Rai
, p. 1393 - 1401 (2008/02/07)
A series of 4-[5-(4,6-disubstituted-2-thiomethyl pyrimidyl)-4'-amino-1,2-4- triazol-3'-yl]thioacetyl-3-arylsydnones 7a-i were synthesized by the reaction of 5-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-3-mercapto-1,2-4-triazoles 3 with 3-aryl-4-bromoacetyl sydnones 6 in an ethanol medium. The newly synthesized compounds 7a-i were screened for their antibacterial activity against E. coli and Serratia marcesens and for antibacterial activity against Aspergillus niger and Pencillium. Most of the tested compounds showed significant antifungal activity particularly against Pencillium at 10-g/mL concentration comparable with that of the standard drug Flukanazole.
1,3-Dibromo-5,5-dimethylhydantoin (DBH) as an efficient promoter for acetylation of 3-arylsydnones in the presence of acetic anhydride under neutral conditions
Azarifar, Davood,Bosra, Hassan Ghasemnejad,Tajbaksh, Mahmood
, p. 467 - 469 (2008/03/29)
(Chemical Equation Presented) 1,3-Dibromo-5,5-dimethylhydantoin (DBH) has been found to efficiently promote the conversion of various 3-arylsydnones to their 4-acetyl congeners in the presence of acetic anhydride under neutral conditions in satisfactory y
