158183-05-2

Usage

Uses

Used in Cancer Treatment:
TAEM is used as a therapeutic agent for the treatment of certain types of cancer. Its chelating properties allow it to bind to metal ions in the body, potentially enhancing the effectiveness of cancer therapies.
Used in Medical Imaging:
As a contrast agent, TAEM is utilized in medical imaging to improve the visualization of internal structures, aiding in the diagnosis and monitoring of various conditions.
Used in Antioxidant Applications:
TAEM is used as an antioxidant, protecting cells from oxidative damage and potentially reducing the risk of certain diseases associated with oxidative stress.
Used in Antimicrobial Applications:
TAEM is employed as an antimicrobial agent, exhibiting activity against various microorganisms, which could be beneficial in the development of new antimicrobial treatments.
Used in Chelation Therapy:
TAEM is used as a chelating agent in cases of heavy metal poisoning, helping to bind and remove toxic metal ions from the body, thus mitigating their harmful effects.
Used in Material Development:
TAEM is utilized in the development of new materials, leveraging its chelating properties to create innovative substances with unique characteristics.
Used in Chemical Reactions:
As a catalyst, TAEM is employed in various chemical reactions to increase their efficiency and speed, contributing to advancements in chemical synthesis and processing.

InChI:InChI=1/C20H22N4O4S3/c1-19(2,3)27-16(26)20(4,5)28-24-14(12-10-29-17(21)22-12)15(25)31-18-23-11-8-6-7-9-13(11)30-18/h6-10H,1-5H3,(H2,21,22)/b24-14-

Upstream product

• 120-78-5 di(benzothiazol-2-yl)disulfide 
• 86299-47-0 (Z)-2-(2-aminothiazol-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxy)iminoacetic acid 

Downstream Products

• 102772-66-7 (Z)-7-(2-(2-aminothiazol-4-yl)-2-(((1-(tertbutoxy)-2-methyl-1-oxopropan-2-yl)oxy)amino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylate 

Relevant academic research and scientific papers

PRODRUG INHIBITORS

Provided herein are compounds useful as metallo-β-lactamase (MBL) inhibitors. The compounds have a formula A–B, where A is a β-lactam antibiotic moiety comprising a bridging methylene (-CH2-) covalently attached to -B; and B is a latent MBL inhibitor. Also provided are formulations comprising such compounds; as well as such compounds or formulations for use as a medicament. The compounds and formulations may be used in the treatment of antibiotic resistance, bacterial infection. The compounds and formulations may be used in the inhibition of a bacterial MBL.

Green process for synthesizing ceftazidime side-chain active ester by using microwave-assisted method

The invention belongs to the technical field of medicines and in particular relates to a green process for synthesizing a ceftazidime side-chain active ester by using a microwave-assisted method. The green process comprises the following steps: by taking a ceftazidime side-chain acid and dithio-bisbenzothiazole as raw materials, and a mixed solution of benzene and acetonitrile as a solvent, under the catalysis of a composite alkali catalyst, dropwise adding triethyl phosphate, performing a microwave-assisted reaction by using a microwave reactor, and performing aftertreatment after the reaction is completed, thereby obtaining a product, wherein the microwave radiation power is 80-300W, and the radiation time is 30-60 minutes. As triethyl phosphate which is low in price is adopted to replace triphenylphosphine which is high in price in the prior art, the production cost can be reduced. The green process for synthesizing the ceftazidime side-chain active ester by using the microwave-assisted method, which is provided by the invention, is low in cost, the production capacity is greatly increased, the yield is increased, that is, up to 97% or greater, the prepared product is relatively high in purity, that is, up to 99% or greater, and a pleasantly surprised technical effect is achieved.

Method for synthesizing 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate

The invention relates to a method for synthesizing 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate and belongs to the technical field of preparation of ceftazidime intermediates. 2-(2-aminothiazole-4-yl)-2-acetic acid and dibenzothiazyl disulfide (DM) are used as raw materials, a dichloromethane and acetonitrile mixed solution serves as a solvent, catalysts pyridine and triethylamine are sequentially added, triethyl phosphite is used as a condensation agent to perform reaction, and suction filtration and drying are performed after reaction is completed to obtain the 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate. The process is simple, mild in condition, low in cost and high in reaction yield, and the prepared target product is high in quality and purity and suitable for mass production.

A modified procedure for synthesis of the side chain of ceftazidime-activated thioester

A modified procedure for synthesis of the side chain of ceftazidime-activated thioester has been established. This key intermediate of ceftazidime was obtained by a more eco-friendly process than conventional methods, and the yield was much higher (up to