1582-24-7Relevant articles and documents
Visible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem-Difluoroalkenes, and Trifluoromethylalkenes
Jiang, Heming,Leng, Jing,Ong, Han-Wee,Wu, Jie,Xu, Wengang
, p. 4009 - 4016 (2020)
Fluorinated organoboranes serve as versatile synthetic precursors for the preparation of value-added fluorinated organic compounds. Recent progress has been mainly focused on the transition-metal catalyzed defluoroborylation. Herein, we report a photocatalytic defluoroborylation platform through direct B?H activation of N-heterocyclic carbene boranes, through the synergistic merger of a photoredox catalyst and a hydrogen atom transfer catalyst. This atom-economic and operationally simple protocol has enabled defluoroborylation of an extremely broad scope of multifluorinated substrates including polyfluoroarenes, gem-difluoroalkenes, and trifluoromethylalkenes in a highly selective fashion. Intriguingly, the defluoroborylation protocol can be transition-metal free, and the regioselectivity obtained is complementary to the reported transition-metal-catalysis in many cases.
The preparation of pentafluorophenyldihaloboranes from pentafluorophenylmercurials C6F5HgR and BX3: the dramatic dependence of the reaction direction on the ligand R
Bardin, Vadim V.,Adonin, Nicolay Yu.
, p. 1523 - 1531 (2019/07/22)
Abstract: In search of convenient preparations of C6F5BX2 (X = Cl, Br), reactions of C6F5HgR (R = C6F5, C6H5, C2H5, Br and Cl) with BX3 were studied. Under the action of BCl3 the order of the C–Hg bond cleavage is C6F5Hg–C6H5 > C6F5–HgC2H5 > C6F5–HgC6F5 >> C6F5–HgCl. With more reactive BBr3 the sequence is C6F5Hg–C6H5 > C6F5–HgC2H5 ~ C6F5Hg–C2H5 > C6F5–HgC6F5 ≥ C6F5–HgBr. During the study we found the simple way to alkyldibromoboranes which is presented by the preparation of C2H5BBr2 from C2H5HgBr and BBr3. It is the second example of synthesis of alkylmercury derivative in an addition to the earlier reported formation of cyclopropylmercurials from di(cyclopropyl)mercury and BX3. Graphic abstract: [Figure not available: see fulltext.].
A five-fluoro phenol preparation method (by machine translation)
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Paragraph 0033; 0034; 0035; 0044; 0049; 0054; 0055; 0059, (2017/08/31)
The invention relates to a five-fluoro phenol preparation method, which belongs to the field of the synthesized compounds. 1 the method comprises the following process steps: five fluoro bromobenzene drop containing magnesium and iodine is added to the organic solvent to obtain Grignard reagent; the resulting Grignard reagent drop to - 20 - 30 °C borate B (OR)3 In the organic solvent solution to carry out the esterification reaction; the resulting five-fluorophenylboronic acid spectrum ether solution with the peroxide in the 10 - 50 °C reaction, the organic solvent is cyclopentyl methyl ether or recovery of the spectrum methyl ether. The present invention only the cyclopentyl methyl ether or recovery of the spectrum methyl ether as the reaction solvent, the solvent refined recovery is, at the same time, the three-step reaction only uses one kind of solvent, solvent variety is single, reduce the operation steps, the production cost is reduced. At the same time the method provided by this invention raw materials are easy, and the process is stable, the operation is convenient, high purity of the product (≥ 99.5%). (by machine translation)
