158221-57-9

Upstream product

• 119878-90-9 (5R)-4-(tert-butyloxycarbonyl)-5-phenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 874368-12-4 (3R,5R)-3-(4-iodobutyl)-2-oxo-5-phenyl-morpholine-4-carboxylic acid tert-butyl ester 
• 158341-07-2 (4R,9aR)-4-Phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 

Downstream Products

• 3105-95-1 pipecolinic acid 

Relevant academic research and scientific papers

An efficient, asymmetric synthesis of pipecolic acid and 2-alkyl pipecolic acids

Both (R)- and (S)-pipecolic acids and their 2-alkyl derivatives have been synthesized via diastereoselective alkylations of (R)-5-phenylmorpholin-2-one 5.

Asymmetric Synthesis. 32. A New Access to Enantiomerically Pure (S)-(-)-Pipecolic Acid and 2- or 6-Alkylated Derivatives

Enantiomerically pure (S)-(-)-pipecolic acid (5) was synthesized in four steps and 47percent overall yield starting from 2-cyano-6-phenyloxazolopiperidine (1).A general strategy is described for preparing 2-alkylated and 6-alkylated pipecolic acid 7a-c and 11a-c using diastereoselective procedures.