158341-07-2

Upstream product

• 119878-90-9 (5R)-4-(tert-butyloxycarbonyl)-5-phenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 874368-12-4 (3R,5R)-3-(4-iodobutyl)-2-oxo-5-phenyl-morpholine-4-carboxylic acid tert-butyl ester 

Downstream Products

• 158221-59-1 (4R,9aS)-9a-Ethyl-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 
• 874368-18-0 (4R,9aS)-9a-propyl-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1-one 
• 158221-57-9 (4R,9aS)-4-Phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 158221-58-0 (4R,9aS)-9a-Methyl-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 
• 3105-95-1 pipecolinic acid 
• 150785-92-5 (R)-2-Benzyl-2-piperidinecarboxylic acid 
• 89115-95-7 (S)-2-Methyl-2-piperidinecarboxylic acid 
• 874368-19-1 (4R,9aS)-9a-allyl-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1-one 
• 158221-60-4 (4R,9aR)-9a-Benzyl-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 

Relevant academic research and scientific papers

An efficient, asymmetric synthesis of pipecolic acid and 2-alkyl pipecolic acids

Both (R)- and (S)-pipecolic acids and their 2-alkyl derivatives have been synthesized via diastereoselective alkylations of (R)-5-phenylmorpholin-2-one 5.

Asymmetric Synthesis. 32. A New Access to Enantiomerically Pure (S)-(-)-Pipecolic Acid and 2- or 6-Alkylated Derivatives

Enantiomerically pure (S)-(-)-pipecolic acid (5) was synthesized in four steps and 47percent overall yield starting from 2-cyano-6-phenyloxazolopiperidine (1).A general strategy is described for preparing 2-alkylated and 6-alkylated pipecolic acid 7a-c and 11a-c using diastereoselective procedures.