158223-63-3Relevant academic research and scientific papers
A metagenomics approach for new biocatalyst discovery: Application to transaminases and the synthesis of allylic amines
Baud, Damien,Jeffries, Jack W. E.,Moody, Thomas S.,Ward, John M.,Hailes, Helen C.
, p. 1134 - 1143 (2017)
Transaminase enzymes have significant potential for the sustainable synthesis of amines using mild aqueous reaction conditions. Here a metagenomics mining strategy has been used for new transaminase enzyme discovery. Starting from oral cavity microbiome samples, DNA sequencing and bioinformatics analyses were performed. Subsequent in silico mining of a library of contiguous reads built from the sequencing data identified 11 putative Class III transaminases which were cloned and overexpressed. Several screening protocols were used and three enzymes selected of interest due to activities towards substrates covering a wide structural diversity. Transamination of functionalized cinnamaldehydes was then investigated for the production of valuable amine building blocks.
Platinum-catalyzed direct amination of allylic alcohols with aqueous ammonia: Selective synthesis of primary allylamines
Das, Kalpataru,Shibuya, Ryozo,Nakahara, Yasuhito,Germain, Nicolas,Ohshima, Takashi,Mashima, Kazushi
supporting information; experimental part, p. 150 - 154 (2012/02/16)
Direct amination of unactivated allylic alcohols with aqueous ammonia was catalyzed by a Pt/phosphine complex to give the corresponding allylamines along with water as the sole by-product. Under optimized reaction conditions, primary allylamines were obtained as major products with excellent monoallylation selectivity. cod=1,5-cyclooctadiene.
1-Aza-1,3-bis(triphenylphosphoranylidene)propane: A Novel =CHCH2N= Synthon
Katritzky, Alan R.,Jiang, Jinlong,Steel, Peter J.
, p. 4551 - 4555 (2007/10/02)
1-Aza-1,3-bis(triphenylphosphoranylidene)propane (3), prepared in situ by the reaction of 1-methyl>benzotriazole (betmip, 4) with methylidenetriphenylphosphorane followed by treatment with butyllithium, enables convenient preparations of 3H-2-benzazepine (7), 2,3-diarylpyrroles 8, and primary allylamines 12 and 13.
