158252-36-9Relevant academic research and scientific papers
Enzyme-catalyzed asymmetric synthesis of optically active (R)-and (S)-ethyl-4-phenyl-4-hydroxybutyrate with microbial cells
Xia, Shiwen,Chen, Yongzheng,Junrui, Zhuo,Xu, Hongmei
, p. 66 - 70 (2013)
In efforts to obtain carbonyl reductases with high activity and enantioselectivity, forty microorganisms belonging to different taxonomical groups were investigated for the ability to catalyze the enantioselective reduction of ethyl 4-phenyl- 4-oxobutyrat
Asymmetric transfer hydrogenation of aryl ketoesters with a chiral double-chain surfactant-type catalyst in water
Li, Jiahong,Lin, Zechao,Huang, Qingfei,Wang, Qiwei,Tang, Lei,Zhu, Jin,Deng, Jingen
supporting information, p. 5367 - 5370 (2017/11/22)
A chiral double-chain surfactant-type ligand was designed and synthesized. The rhodium catalyst formed from the ligand can self-assemble into chiral vesicular aggregates in water, which was applied to the ATH of a broad range of aromatic ketoesters in neat water and gave up to 99% yield and 99% ee. In addition, this double-chain surfactant-type catalyst could also be applied to the dynamic kinetic resolution (DKR) of bicyclic β-ketoesters in water.
Cobalt-catalyzed asymmetric hydroboration of aryl ketones with pinacolborane
Guo, Jun,Chen, Jianhui,Lu, Zhan
supporting information, p. 5725 - 5727 (2015/03/30)
The highly enantioselective cobalt-catalyzed hydroboration reaction of aryl ketones with HBpin was developed using iminopyridine oxazoline ligands. Halides, amines, ethers, sulfides, esters and amides are well tolerated under the mild reaction conditions, demonstrating its synthetic advantage. Substituted diaryl ketones could also be hydroborated with high enantioselectivity.
Simple 1,3-diamines and their application as ligands in ruthenium(II) catalysts for asymmetric transfer hydrogenation of aryl ketones
Facchetti, Giorgio,Gandolfi, Raffaella,Fusè, Marco,Zerla, Daniele,Cesarotti, Edoardo,Pellizzoni, Michela,Rimoldi, Isabella
, p. 3792 - 3800 (2015/05/20)
In this research work simple unsymmetrical 1,3-diamines were studied. The synthesis of the diamines started from non-commercial available compounds. S-5a and S,S-5c were obtained by biocatalysis with non conventional yeast, Rhodotorula rubra MIM 147, with
Stereodivergent preparation of valuable γ- Or δ-hydroxy esters and lactones through one-pot cascade or tandem chemoenzymatic protocols
Diaz-Rodriguez, Alba,Borzeicka, Wioleta,Lavandera, Ivan,Gotor, Vicente
, p. 386 - 393 (2014/03/21)
A series of enantiopure hydroxy esters and lactones has been synthesized in a chemodivergent manner via alcohol dehydrogenase (ADH) reduction of the corresponding keto esters by means of cascade or tandem protocols. Thus, ADH from Rhodococcus ruber (ADH-A) or Lactobacillus brevis (LBADH) afforded both antipodes in a very selective way when dealing with small derivatives. With bulkier substrates, ADH from Ralstonia sp. (RasADH) was successfully employed to achieve the synthesis of enantioenriched γ- or δ-hydroxy esters. To isolate the corresponding lactones, two different approaches were followed: a cascade reaction by spontaneous cyclization of the hydroxy ester intermediate, or a one-pot two-step tandem protocol. Moreover, a chemoenzymatic route was designed to obtain a chiral brominated lactone, which enabled further modifications in a sequential fashion by Pd-catalyzed reactions, affording relevant functionalized lactones.
