1582806-75-4

Basic information

• Product Name: (S)-3-(4-bromophenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
• Synonyms: (S)-3-(4-bromophenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
• CAS NO: 1582806-75-4
• Molecular Weight: 589.264
• Mol File: 1582806-75-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-3-(4-bromophenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-bromophenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide(1582806-75-4)
• EPA Substance Registry System: (S)-3-(4-bromophenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide(1582806-75-4)

Safety Data

• Hazardous Substances Data: 1582806-75-4(Hazardous Substances Data)

Upstream product

• 4192-28-3 Phth-L-Ala-OH 
• 4306-25-6 (S)-2-phthalimidopropionyl chloride 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 1582806-46-9 (S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide 
• 18954-74-0 (4-bromophenyl)triethoxysilane 
• 589-87-7 1,4-bromoiodobenzene 

Relevant articles and documents

Functionalized Polymer-Supported Pyridine Ligands for Palladium-Catalyzed C(sp3)-H Arylation

The use of ligands to tune the reactivity and selectivity of transition-metal catalysts for C(sp3)-H bond activation is a current central challenge. One of us previously developed an uncommon example of a homogeneous catalyst that performs controlled C(sp3)-H arylation using pyridine derivatives as ligands, along with Pd [Science, 2014, 343, 1216-1220]. In this work, we report a functionalizable and tunable polymer support used in the immobilization of pyridine derivatives that yields a soluble, polymeric ligand platform facilitating C(sp3)-H activation reactions with good yields, selectivities differing from the homogeneous catalyst, and recovery of Pd. Unlike the homogeneous system, the supported catalysts in Pd-catalyzed C-H monoarylation reactions respond sensitively to the steric hindrance of the coupling partners.

Ligand-Enabled Cross-Coupling of C(sp3)-H Bonds with Arylsilanes

Pd(II)-catalyzed cross-coupling of C(sp3)-H bonds with organosilicon coupling partners has been achieved for the first time. The use of a newly developed quinoline-based ligand is essential for the cross-coupling reactions to proceed.