1583-66-0

Usage

Uses

5-Fluoroisophthalic Acid is a useful research chemical.

InChI:InChI=1/C8H5FO4/c9-6-2-4(7(10)11)1-5(3-6)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 461-97-2 3,5-dimethylfluorobenzene 
• 518070-19-4 3-fluoro-5-methylbenzoic acid 
• 108-69-0 3,5-dimethylaminoaniline 

Downstream Products

• 17449-48-8 dimethyl 5-fluoroisophthalate 
• 19254-86-5 (5-fluoro-1,3-phenylene)dimethanol 
• 20330-80-7 5-fluoroisophthalamide 

Relevant academic research and scientific papers

Effect of Substituents at the 5-Position on the First and Second Dissociation Constants of Isophthalic Acid

The dissociation constants of benzoic acid and 20 of its meta- or para-substituted derivatives and of isophthalic acid and ten of its 5-substituted derivatives have been measured in 50 wtpercent aqueous methanol.The Hammett ρ value for benzoic acid is 1.28; for isophthalic acid the ρ values are 1.21 (pK1) and 1.20 (pK2).The ?meta values for hydroxy and acetoxy are -0.01 and +0.29, respectively, in this system.Values for ?meta for CO2H and CO2- are calculated to be +0.28 and -0.20, respectively; however there are indications that these values are not completely structure-independent.

CHEMICAL COMPOUNDS

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The present invention provides novel beta-secretase inhibitors of the general formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.

Herbicidal method

The invention relates to a method for the control of weeds (i.e. undesired vegetation) at a locus, which method comprises applying thereto a herbicidally effective amount of at least one compound which is a 3,5-dicyanophenoxy derivative of formula (I): wherein A is as defined in the description; to novel 3,5-dicyanophenoxy derivatives, to new herbicidal compositions containing them, and to processes and intermediates for their preparation.