17449-48-8 Usage
Description
5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER, also known as Dimethyl 5-Fluoroisophthalate, is an organic compound derived from isophthalic acid. It is characterized by the presence of a fluorine atom at the 5th position and two methyl ester groups attached to the benzene ring. 5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and reactivity.
Uses
Used in Pharmaceutical Industry:
5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER is used as a reactant for the preparation of quinazoline compounds, which are known as B-Raf inhibitors. These inhibitors play a crucial role in the development of targeted therapies for various types of cancer, as they help in modulating the activity of the B-Raf protein, a key component in cell signaling pathways involved in tumor growth and progression.
Check Digit Verification of cas no
The CAS Registry Mumber 17449-48-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,4 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17449-48:
(7*1)+(6*7)+(5*4)+(4*4)+(3*9)+(2*4)+(1*8)=128
128 % 10 = 8
So 17449-48-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H9FO4/c1-14-9(12)6-3-7(10(13)15-2)5-8(11)4-6/h3-5H,1-2H3
17449-48-8Relevant articles and documents
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Boekelheide,V.,Griffin,R.W.
, p. 1960 - 1961 (1969)
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Application of trivalent iodine compounds as catalysts in Bal-Schiemann reaction
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Paragraph 0154; 0159, (2018/10/19)
The invention discloses an application of trivalent iodine compounds shown in formula I and/or II in the description and used as catalysts in Bal-Schiemann reaction. The trivalent iodine compounds areused as the catalysts in the Bal-Schiemann reaction, so that the Bal-Schiemann reaction can be conducted at room temperature or near room temperature when a thermochemical method is used, and the reaction has mild reaction conditions, wide substrate use range and short reaction time, and is safe and easy to operate, products are easy to separate, and raw materials are simple and low in toxicity.
NEW COMPOUNDS
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Page 100-101, (2010/02/06)
The present invention relates to new compounds of formula I, (I) a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
