17449-48-8

Usage

Uses

Used in Pharmaceutical Industry:
5-FLUOROISOPHTHALIC ACID DIMETHYL ESTER is used as a reactant for the preparation of quinazoline compounds, which are known as B-Raf inhibitors. These inhibitors play a crucial role in the development of targeted therapies for various types of cancer, as they help in modulating the activity of the B-Raf protein, a key component in cell signaling pathways involved in tumor growth and progression.

InChI:InChI=1/C10H9FO4/c1-14-9(12)6-3-7(10(13)15-2)5-8(11)4-6/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 1583-66-0 5-fluoroisophthalic acid 
• 99-27-4 dimethyl 5-aminoisophthalate 

Downstream Products

• 19254-80-9 1,3-bis(bromomethyl)-5-fluorobenzene 
• 1393561-99-3 methyl 3-fluoro-5-formylbenzoate 
• 660416-37-5 methyl 3-fluoro-5-(hydroxymethyl)benzoate 
• 660416-36-4 3-fluoro-5-(methoxycarbonyl)benzoic acid 
• 19254-86-5 (5-fluoro-1,3-phenylene)dimethanol 

Relevant academic research and scientific papers

Hypervalent Iodine(III)-Catalyzed Balz–Schiemann Fluorination under Mild Conditions

An unprecedented hypervalent iodine(III) catalyzed Balz–Schiemann reaction is described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeds under mild conditions (25–60 °C), and features a wide substrate scope and good functional-group compatibility.

Application of trivalent iodine compounds as catalysts in Bal-Schiemann reaction

The invention discloses an application of trivalent iodine compounds shown in formula I and/or II in the description and used as catalysts in Bal-Schiemann reaction. The trivalent iodine compounds areused as the catalysts in the Bal-Schiemann reaction, so that the Bal-Schiemann reaction can be conducted at room temperature or near room temperature when a thermochemical method is used, and the reaction has mild reaction conditions, wide substrate use range and short reaction time, and is safe and easy to operate, products are easy to separate, and raw materials are simple and low in toxicity.

CHEMICAL COMPOUNDS

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

NEW COMPOUNDS

The present invention relates to new compounds of formula I, (I) a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.