158327-23-2Relevant academic research and scientific papers
Technetium-99m N,N'-Bis(2-mercapto-2-methylpropyl)-2-aminobenzylamine: Technetium-99m Complexes of a Novel Bis(aminoethanethiol) Ligand
Francesconi, Lynn C.,Yang, Yun Y.,Kung, Mei-Ping,Zhang, Xiao X.,Billings, Jeffrey J.,et al.
, p. 3282 - 3288 (2007/10/02)
A new N2S2 ligand system, N,N'-bis(2-mercapto-2-methylpropyl)-2-aminobenzylamine, U-BAT, 1, containing uneven amine groups (two amine groups with different pKa values) for complexing VO>3+, was prepared.The reaction of this novel ligand with pertechnetate, in the presence of stannous tartrate as the reducting agent, produces the neutral and lipid-soluble TcVO(U-BAT), TcS2C15H23N2O, 2.However, when the same reaction was carried out at a higher pH, 9-10, and with 30 min of heating (100 deg C), a second neutral but more lipid-soluble complex, TcVO(OU-BAT), TcS2C15H21N2O, 3, was isolated.The X-ray crystallography data of the 99Tc complexes show square pyramidal coordination with N2S2 as the base and the Tc=O in the apical position.Compound 3 can be derived from 2 by an oxidation of the ligand to form an imine.After iv injection into rats, the neutral and lipid-soluble technetium-99m complexes showed significant brain uptake, 1.54 and 1.07percent dose/organ at 2 min for TcVO(U-BAT) and TcVO(OU-BAT), respectively.The novel Tc chemistry of this new ligand system may provide a useful foundation for designing Tc complexes with a built-in redox mechanism.
