15833-80-4

Usage

InChI:InChI=1/C6H14O3/c1-6(2,4-8)5(9)3-7/h5,7-9H,3-4H2,1-2H3

Upstream product

• 79-50-5 pantolactone 
• 371198-80-0 3,3-dimethyl-2-(2-tetrahydrofuryloxy)-4-butanolide 
• 5447-64-3 diethyl 3,3-dimethyl-2-ketosuccinate 
• 371198-97-9 3,3-dimethyl-2-(2-tetrahydrofuryloxy)-1,4-butanediol 

Downstream Products

• 1329997-15-0 (4R,5R,9R,10R)-1,4-bis(benzyloxy)-11-(tert-butyldimethylsilyloxy)-9,10-(2,2-dimethyl-1,3-dioxolane)-5-hydroxy-2,2-dimethylundecan-3,7-dione 
• 1329997-14-9 (4R,5R,9R,10R)-1,4-bis(benzyloxy)-11-(tert-butyldimethylsilyloxy)-9,10-(2,2-dimethyl-1,3-dioxolane)-5-methoxy-2,2-dimethylundecan-3,7-dione 
• 1329997-13-8 (4R,5R,9R,10R)-1,4-bis(benzyloxy)-11-(tert-butyldimethylsilyloxy)-9,10-(2,2-dimethyl-1,3-dioxolane)-7-(1,3-dithiane)-5-hydroxy-2,2-dimethylundecan-3-one 
• 1329997-09-2 (Z)-1,4-dibenzyloxy-3,3-dimethyl-2-(trimethylsilyloxy)-1-butene 

Relevant academic research and scientific papers

Geminal dimethyl-substituted functionalized C4-synthons from pantolactone

Some geminal dimethyl-substituted functionalized C4-synthons were prepared on the basis of (±)-pantolactone.

CYCLIC COMPOUNDS AND METHODS OF USING SAME

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof which are MALT1 inhibitors. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF

Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: Formula (I) and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

AURISTATIN DERIVATIVES AND CONJUGATES THEREOF

Disclosed herein are novel compounds of formula (I) as described herein, and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.