158351-87-2

Basic information

• Product Name: 4H-Pyran-4-one, tetrahydro-3-(trifluoroacetyl)- (9CI)
• Synonyms: 4H-Pyran-4-one, tetrahydro-3-(trifluoroacetyl)- (9CI)
• CAS NO: 158351-87-2
• Molecular Formula: C7H7F3O3
• Molecular Weight: 196.1238896
• Product Categories: ACETYLHALIDE
• Mol File: 158351-87-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4H-Pyran-4-one, tetrahydro-3-(trifluoroacetyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyran-4-one, tetrahydro-3-(trifluoroacetyl)- (9CI)(158351-87-2)
• EPA Substance Registry System: 4H-Pyran-4-one, tetrahydro-3-(trifluoroacetyl)- (9CI)(158351-87-2)

Safety Data

• Hazardous Substances Data: 158351-87-2(Hazardous Substances Data)

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 1022931-45-8 3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole 
• 1022930-47-7 1-({2,6-difluoro-4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-33-1 1-({4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-30-8 1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole 

Relevant articles and documents

Fused 3-hydroxy-3-trifluoromethylpyrazoles inhibit mutant huntingtin toxicity

Here, we describe the selection and optimization of a chemical series active in both a full-length and a fragment-based Huntington's disease (HD) assay. Twenty-four thousand small molecules were screened in a phenotypic HD assay, identifying a series of compounds bearing a 3-hydroxy-3- trifluoromethylpyrazole moiety as able to revert the toxicity induced by full-length mutant Htt by up to 50%. A chemical exploration around the series led to the identification of compound 4f, which demonstrated to be active in a Htt171-82Q rat primary striatal neuron assay and a PC12-Exon-1 based assay. This compound was selected for testing in R6/2 mice, in which it was well-tolerated and showed a positive effect on body weight and a positive trend in preventing ventricular volume enlargment. These studies provide strong rationale for further testing the potential benefits of 3-hydroxy-3-trifluoromethylpyrazoles in treating HD.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compounds of formula (I), and salts and solvates thereof are provided: Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compound of formula (I) and salts thereof are provided: wherein A, R1, R, R2 are as defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.