158365-49-2Relevant academic research and scientific papers
Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity
Oh, Seikwan,Moon, Hyung-In,Son, Il-Hong,Jung, Jae-Chul
, p. 1125 - 1135 (2007)
A simple synthesis of sulfonamides 4-22 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involve N-sulfonylation of L-proline benzyl ester hydrochloride (2) and coupling reaction of N-sulfonyl chloride 3 with amine
N-Chlorosulfonyl-L-proline Benzyl Ester
Ibbett, Ashley J.,Watkin, David J.
, p. 1283 - 1284 (1994)
The crystal structure reported for the title compound, C12H14ClNO4S, (I), is the first for a sulfamoyl chloride.
Compounds, compositions, and methods for stimulating neuronal growth and elongation
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, (2008/06/13)
The present invention concerns methods, pharmaceutical compounds, and compositions for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.
Azasulfonamidopeptides as Peptide Bond Hydrolysis Transition State Analogues. Part 1. Synthetic Approaches
Cheeseright, Timothy J.,Edwards, Alison J.,Elmore, Donald T.,Jones, John H.,Raissi, Maryam,Lewis, Elsa C.
, p. 1595 - 1600 (2007/10/02)
The title compounds, a novel class of peptide analogues in which an α-amino acid residue is replaced by a hydrazine-1,2-diyl sulfonyl group -NHNRSO2-, are of potential interest as proteinase inhibitors.Synthetic approaches to such compounds and the X-ray
