15837-43-1

Basic information

• Product Name: Acetamide, 2-cyano-1-[(phenylamino)carbonyl]-
• CAS NO: 15837-43-1
• Molecular Formula: C10H9N3O2
• Molecular Weight: 203.2
• Mol File: 15837-43-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-cyano-1-[(phenylamino)carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-cyano-1-[(phenylamino)carbonyl]-(15837-43-1)
• EPA Substance Registry System: Acetamide, 2-cyano-1-[(phenylamino)carbonyl]-(15837-43-1)

Safety Data

• Hazardous Substances Data: 15837-43-1(Hazardous Substances Data)

Upstream product

• 64-10-8 phenyl carbamate 
• 372-09-8 cyanoacetic acid 
• 93-97-0 benzoic acid anhydride 
• 103-71-9 phenyl isocyanate 
• 90771-16-7 N-Cyano-acetylcarbaminsaeure-phenylester 
• 62-53-3 aniline 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 15886-45-0 6-amino-5-nitroso-1-phenyl-1,3-dihydropyrimidine-2,4-dione 
• 138574-77-3 2-Oxo-1,4-diaza-spiro[4.5]dec-3-ene-1,3-dicarboxylic acid 3-amide 1-phenylamide 
• 15837-45-3 6-amino-1-phenyluracil 
• 146494-88-4 3-Amino-2-oxo-1,4-diaza-spiro[4.5]decane-1,3-dicarboxylic acid 3-amide 1-phenylamide 
• 75130-08-4 1-{2-Cyano-2-[(E)-hydroxyimino]-acetyl}-3-phenyl-urea 
• 36981-02-9 C₁₃H₁₄N₄O₂ 

Relevant articles and documents

Carboxylic acid-catalyzed one-pot synthesis of cyanoacetylureas and their cyclization to 6-aminouracils in guanidine ionic liquid

A novel, one-pot, carboxylic acid-catalyzed synthesis of cyanoacetylureas via in situ generated ureas and their cyclization to 6-aminouracils in the presence of the guanidine-based ionic liquid 1,1,3,3-tetramethylguanidine lactate [TMG][Lac] is described. The ureas were synthesized from amines and potassium cyanate, which on reaction with cyanoacetic acid in the presence of acetic anhydride in the same pot afforded cyanoacetylureas, which undergo cyclization in [TMG][Lac] as solvent as well as catalyst to afford 6-aminouracils. One-pot synthesis of cyanoacetylureas, efficient and rapid cyclization, better yield, shorter reaction time, easy workup procedure, and recyclability of the ionic liquid are some advantages of this procedure.

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.

Tricyclic Pyrimidine Derivatives as Wnt antagonists

The present invention relates to compounds having the general formula (I) with the definitions of X1 - X3, Y1, Y2, L1, R1 and R2 given below and/or solvates, hydrates, esters and pharmaceutically acceptable salts thereof. Furthermore, the invention relates to the use of said compounds for modulating of the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.