15837-46-4

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 103-85-5 monophenylthiourea 
• 15837-44-2 1-Phenyl-3-cyanacetyl-thioharnstoff 

Downstream Products

• 15112-10-4 1-phenyl-2-thioxodihydropyrimidine-4,6(1H,5H)dione 
• 15837-45-3 6-amino-1-phenyluracil 
• 898131-40-3 N-{4,6-dioxo-1-phenyl-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide 
• 900091-10-3 N-{5-[(4,6-dioxo-2-thioxo-5-trifluoromethyl-1-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidine-5-yl)sulfamoyl]-1,3,4-thiadiazol-2-yl}acetamide 

Relevant academic research and scientific papers

Reactions of nitriles under acidic conditions : Part IX - Synthesis of 6-amino-1-aryluracils, 6-amino-1-aryl-2-thiouracils and 6-amino-1,3-diaryl-2-thiouracils under acidic conditions

6-Amino-1-aryluracils (11a-g), 6-amino-1-aryl-2-thiouracils (12a-g), and 6-amino-1,3-diaryl-2-thiouracils (6a,b) have been synthesised through the dry hydrogen chloride gas-catalysed condensation of ethyl cyanoacetate (7) with appropriate arylureas and thioureas. 1-Aryl (12a-g) and 1,3-diaryl-2-thiouracils (6c-g) have been converted to the corresponding 1-aryl (15a-g) and novel hitherto unre-ported, 1,3-diaryluracils (5a-e) through their oxidative desulphurisation.