158392-63-3

Upstream product

• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 17851-98-8 1-phenyl-1-(tributylstannyloxy)ethene 

Downstream Products

• 133957-56-9 3,4-epoxy-1,3-diphenyl-1-butanoate 
• 495-71-6 phenacylacetophenone 
• 5369-55-1 2,4-diphenylfuran 
• 3442-15-7 1,4-diphenylbutane-1,3-dione 

Relevant academic research and scientific papers

Zinc-mediated C-C bond sigmatropic rearrangement: A new and efficient methodology for the synthesis of β-diketones

(Chemical Equation Presented) A new and efficient methodology has been developed for the synthesis of β-diketones from aromatic α-bromo ketones in the presence of Furukawa reagent under mild conditions. The present transformation is proposed to proceed via a Reformatsky-type reaction of α-bromo ketones, followed by C-C bond sigmatropic rearrangement of the aldolate intermediate to give β-diketones in moderate to good isolated yields, while aliphatic α-bromomethyl ketones resulted in the formation of 2,4-disubstituted furans or cis-1,2-disubstituted cyclopropanols in moderate yields. The scope of this process was investigated, and a tentative mechanism was proposed.

One step preparation of 1,4-diketones from methyl ketones and α-bromomethyl ketones in the presence of ZnCl2·t-BuOH·Et2NR as a condensation agent

1,4-Diketones have been prepared in one step from methyl ketones and α-bromomethyl ketones under the action of ZnCl2·t-BuOH·Et2NR as a condensation agent with moderate to high yields. The mechanistic pathway of the reaction is proposed to go through aldol condensation of ketones followed by 1,3-dehydro-bromination of aldol products and cleavage of activated cyclopropyl intermediates.

A new simple synthesis of aryl-substituted 1,4-diketones

1,4-Diketones have been prepared by aldol condensation of methyl ketones with α-bromo ketones in the presence of tert-butoxymagnesium or diethylamido magnesium bromide and subsequent rearrangement of the formed 4-bromo-3-hydroxy ketones under the action o

NMR Studies of Five-Coordinate Tin Enolate: An Efficient Reagent for Halo Selective Reaction toward α-Halo Ketone or α-Halo Imine

NMR studies of tin enolates 1, in the presence of HMPA, revealed the presence of a five-coordinate O-stannyl enolate 1(h) which contributes to upfield shifts of Sn peaks in the 119Sn NMR spectrum and increased coupling constants J(119Sn-13C), compared wit

SYNTHESIS OF 1,4-DIKETONES, 3,4-EPOXY KETONES, AND 2,4-DISUBSTITUTED FURANS BASED ON THE PRODUCTS FROM CONDENSATION OF THE MAGNESIUM ENOLATES OF KETONES WITH α-BROMO KETONES

4-Bromo-3-hydroxy ketones were obtained by the condensation of methyl ketones with 2-bromo ketones in the presence of tert-butoxymagnesium bromide or by the action of organomagnesium compounds on 2-bromo ketones.The reaction of 4-bromo-3-hydroxy ketones w