158407-19-3Relevant academic research and scientific papers
Self-replicating molecules: A second generation
Wintner, Edward A.,Conn, M. Morgan,Rebek Jr., Julius
, p. 8877 - 8884 (2007/10/02)
The use of self-complementary structures in replication experiments is discussed, and a second generation of self-replicating molecules is introduced. Key design elements of the new system are described, specifically a high affinity (Ka ～ 105 M-1 in CDCl3) between the two complementary reactive components and the careful placement of nucleophilic and electrophilic centers within the system. These considerations preclude intramolecular reactions within two-component complexes, thus minimizing undesirable background reactions. Autocatalysis is observed in the new systems, and by using appropriate control experiments the autocatalysis is traced to template effects.
