1584219-81-7

Basic information

• Product Name: N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• CAS NO: 1584219-81-7
• Molecular Weight: 593.611
• Mol File: 1584219-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide(1584219-81-7)
• EPA Substance Registry System: N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide(1584219-81-7)

Safety Data

• Hazardous Substances Data: 1584219-81-7(Hazardous Substances Data)

Upstream product

• 261925-02-4 3-((methylsulfonyl)methyl)aniline 
• 1584220-19-8 4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine 
• 849217-48-7 ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid 
• 1584220-15-4 4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine 
• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 40258-99-9 1-(chlorocarbonyl)cyclopropane-1-carboxylic acid 

Relevant articles and documents

Discovery of anilinopyrimidines as dual inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and cellular activity

Both c-Met and VEGFR-2 are important targets for cancer therapies. Here we report a series of potent dual c-Met and VEGFR-2 inhibitors bearing an anilinopyrimidine scaffold. Two novel synthetic protocols were employed for rapid analoguing of the designed