158461-32-6

Upstream product

• 110-86-1 pyridine 
• 16554-47-5 3-methoxy-2-nitroaniline 
• 4373-58-4 2-(3-methoxyphenyl)pyridine 
• 158461-29-1 tert-butyl N-(2-nitro-3-methoxyphenyl)carbamate 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 

Downstream Products

• 158461-77-9 {1-Methyl-2-[2-pyridin-2-yl-6-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 158461-73-5 [2-(2-Methoxy-6-pyridin-2-yl-phenylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester 
• 158461-37-1 2-[2-Nitro-3-(2,2,2-trifluoro-ethoxy)-phenyl]-pyridine 
• 158461-51-9 2-Pyridin-2-yl-6-(2,2,2-trifluoro-ethoxy)-phenylamine 
• 159958-45-9 2-(3-hydroxy-2-nitrophenyl)pyridine 
• 158461-47-3 2-Methoxy-6-pyridin-2-yl-phenylamine 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed azidation and nitration of arenes by C-H activation

Getting a handle on it: In the chelation-assisted title reactions in the presence of a hypervalent iodine oxidant, sodium azide and sodium nitrite served as readily available nitrogen sources, and pyridine, pyrimidine, and pyrazole substituents were effic

Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative

A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.