158461-41-7

Basic information

• Product Name: 3-(4-isopropoxy-2-nitrophenyl)pyridine
• Synonyms: 3-(4-isopropoxy-2-nitrophenyl)pyridine
• CAS NO: 158461-41-7
• Molecular Weight: 258.277
• Mol File: 158461-41-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-isopropoxy-2-nitrophenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-isopropoxy-2-nitrophenyl)pyridine(158461-41-7)
• EPA Substance Registry System: 3-(4-isopropoxy-2-nitrophenyl)pyridine(158461-41-7)

Safety Data

• Hazardous Substances Data: 158461-41-7(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 96-96-8 4-methoxy-2-nitroaniline 
• 4373-75-5 3-(4-methoxy-2-nitrophenyl)-pyridine 
• 75-30-9 2-iodo-propane 
• 119289-79-1 3-(4-hydroxy-2-nitrophenyl)pyridine 

Downstream Products

• 158461-87-1 N-(5-Isopropoxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide 
• 158461-58-6 5-Isopropoxy-2-pyridin-3-yl-phenylamine 

Relevant articles and documents

Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative

A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.