1584632-98-3Relevant academic research and scientific papers
Palladium-catalyzed oxidative annulation of acrylic acid and amide with alkynes: A practical route to synthesize α-pyrones and pyridones
Yu, Yue,Huang, Liangbin,Wu, Wanqing,Jiang, Huanfeng
, p. 2146 - 2149 (2014/05/06)
A range of internal alkynes smoothly underwent palladium-catalyzed oxidative annulations with acrylic acid and amide to afford α-pyrones and pyridones in good to excellent yields with high regioselectivity. The usage of O2 (1 atm) as a stoichiometric oxidant with H2O as the only byproduct under mild conditions makes this process more attractive and practical.
