158468-93-0

Upstream product

• 212309-05-2 2-(acetylthio)ethyl tetra-O-acetyl-α-D-mannopyranoside 
• 4163-65-9 per-O-acetyl-α-D-mannopyranose 
• 110891-64-0 2'-bromoethyl-α-D-mannopyranoside 
• 849420-02-6 (2-chloroethyl)-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 358750-84-2 2-thioethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 7296-15-3 alpha-D-mannopyranoside 
• 16977-78-9 2'-bromoethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 

Relevant academic research and scientific papers

A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria

We report a remarkably facile one-pot sonochemical approach to prepare protein microspheres whose shells are covalently decorated with a mannosyl derivative to target Escherichia coli (E. coli), while their cores are encapsulated with tetracycline. Conjugated microspheres induced the agglutination of E. coli and increased the anti-bacterial activity of the encapsulated tetracycline by five fold.

A Bifunctional Spin Label for Ligand Recognition on Surfaces

In situ monitoring of biomolecular recognition, especially at surfaces, still presents a significant technical challenge. Electron paramagnetic resonance (EPR) of biomolecules spin-labeled with nitroxides can offer uniquely sensitive and selective insights into these processes, but new spin-labeling strategies are needed. The synthesis and study of a bromoacrylaldehyde spin label (BASL), which features two attachment points with orthogonal reactivity is reported. The first examples of mannose and biotin ligands coupled to aqueous carboxy-functionalized gold nanoparticles through a spin label are presented. EPR spectra were obtained for the spin-labeled ligands both free in solution and attached to nanoparticles. The labels were recognized by the mannose-binding lectin, Con A, and the biotin-binding protein avidin-peroxidase. Binding gave quantifiable changes in the EPR spectra from which binding profiles could be obtained that reflect the strength of binding in each case.

Glucose- and pH-responsive controlled release of cargo from protein-gated carbohydrate-functionalized mesoporous silica nanocontainers

Learning to let go: Controlled release of cargo (purple cubes) from lectin (blue squares)-gated nanopores was achieved using mannose (green loops)-functionalized mesoporous silica (see scheme). The protein nanogates could be opened either by decreasing the pH of the buffer or by adding competing glucose (yellow rings) to release the cargo from the pores. Copyright

Thioctic acid amides: Convenient tethers for achieving low nonspecific protein binding to carbohydrates presented on gold surfaces

The thioctic acid amides of 2′-aminoethyl α-D-mannopyranoside and 2′-aminoethyl α-1,3-D-mannopyranosyl (α-1,6-D- mannopyranosyl)-α-D-mannopyranoside presented on both planar and nanoparticle gold surfaces give higher specific and lower non-specific protei

Synthesis of Clustered Glycoside - Antigen Conjugates by Two One-Pot, Orthogonal, Chemoselective Ligation Reactions: Scope and Limitations

Major histocompatibility class II antigens have been bound to clustered glycosides for selective targeting of the dendritic cell mannose receptor. Di-, tetra-, and octavalent glycoside - antigen conjugates have been obtained after two, orthogonal, hydrazo

Convergent synthesis of fluorescein-labelled lysine-based cluster glycosides

The synthesis of fluorescein-labelled lysinyl trees, containing 2, 4 or 8 manno- or galactoside residues, is reported. These lysine-based cluster glycosides have been readily assembled by coupling amino-functionalized, N-chloroacetylated-L-lysinyl trees w