7296-15-3

Basic information

• Product Name: α-D-Mannopyranose
• Synonyms: alpha-D-Mannopyranose;alpha-D-Mannose;alpha-Mannose
• CAS NO: 7296-15-3
• Molecular Formula: C₆H₁₂O₆
• Molecular Weight: 180.16
• Mol File: 7296-15-3.mol

Chemical Properties

• Melting Point: 133 °C
• Boiling Point: 410.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.732±0.06 g/cm3(Predicted)
• PKA: 12.12±0.70(Predicted)
• CAS DataBase Reference: α-D-Mannopyranose(CAS DataBase Reference)
• NIST Chemistry Reference: α-D-Mannopyranose(7296-15-3)
• EPA Substance Registry System: α-D-Mannopyranose(7296-15-3)

Safety Data

• Hazardous Substances Data: 7296-15-3(Hazardous Substances Data)

Usage

Uses

Used in Biomedicine:
α-D-Mannopyranose is used as a research target for understanding its role in cell signaling, hormone regulation, and immune response, which is crucial for developing new therapeutic strategies and interventions in various diseases.
Used in Biochemistry:
α-D-Mannopyranose is used as a key component in the study of glycoproteins, glycolipids, and cell surface receptors, which are essential for understanding the molecular mechanisms of various biological processes.
Used in Pharmaceutical Sciences:
α-D-Mannopyranose is used as a potential target for drug development, given its involvement in critical biological processes. Its presence in biological molecules makes it a promising candidate for the design of new drugs and therapeutic agents.

InChI:InChI=1/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1

Upstream product

• 10357-27-4 4-nitrophenyl-α-D-mannopyranoside 

Downstream Products

• 41308-76-3 allyl α-D-mannopyranoside 
• 15548-45-5 (2S,3S,4S,5S,6R)-2-benzyloxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol 
• 2592-58-7 1,2,3,4,6-penta-O-benzoyl-α-D-mannopyranoside 
• 26301-79-1 D-mannono-1,4-lactone 
• 83-87-4 D-Mannose pentaacetate 
• 82598-88-7 2,3,4,6-tetra-O-benzyl-D-mannono-1,5-lactone 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 51970-29-7 α-D-mannopyranosyl azide 
• 1609083-15-9 2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl-α-D-mannopyranoside 
• 124-38-9 carbon dioxide 
• 1333-74-0 hydrogen 
• 140428-83-7 2-azidoethyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 158468-93-0 (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-(2-mercaptoethoxy)tetrahydro-2H-pyran-3,4,5-triol 
• 16977-78-9 2'-bromoethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 

Relevant articles and documents

Creation of an α-mannosynthase from a broad glycosidase scaffold

α-Mannosides made easy: Mutation of a family-GH31 α-glucosidase that displays plasticity to alterations at the 2-OH position of donor substrates created an efficient α-mannoside-synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono-α-mannosylated conjugates using the α-mannosynthase displaying low (unwanted) oligomerization activity. Copyright

Separation of yeast asparagine-linked oligosaccharides by high-performance anion-exchange chromatography.

Oligosaccharides obtained from Saccharomyces cerevisiae mannoproteins by digestion with endo-N-acetyl-beta-D-glucosaminidase H were fractionated by anion-exchange chromatography, by elution with 50-100mM NaOH without or with a sodium-acetate gradient, and detected with a pulsed amperometric detector (PAD). The elution times of homologous oligosaccharides fell on a straight line having a slope characteristic of the structural type. The response of the PAD detector per mole of oligosaccharide increased about 2-fold going from Man3GlcNAc to Man13GlcNAc, and appeared to depend primarily on the oxidation of the reducing-end N-acetylglucosamine unit common to all the oligosaccharides. The digestion of a Man10GlcNAc with jack-bean alpha-mannosidase was monitored by injecting portions of the crude reaction mixture, and the intermediates were characterized by their elution positions and n.m.r. spectra in the anomeric proton region. One commercial jack-bean alpha-mannosidase preparation contained a novel endolytic activity that released N-acetylglucosamine from the reducing ends of the oligosaccharides and was shown to convert P----6 alpha Man----6 alpha Man----6 beta Man----4 alpha beta GlcNAc to P----6 alpha Man----6 alpha Man----6 alpha beta Man plus free N-acetylglucosamine. Another commercial jack-bean alpha-mannosidase converted the Man10GlcNAc to a Man3GlcNAc having the structure alpha Man----6 beta Man----4 alpha beta GlcNAc, [formula: see text] whereas the Oerskovia sp. alpha-mannosidase converted the same oligosaccharide to a Man4GlcNAc having the structure alpha Man----6 alpha Man----6 beta Man----4 alpha beta GlcNAc. [formula: see text]