1584705-64-5Relevant academic research and scientific papers
Copper-catalyzed trifluoromethylthiolation of aryl halides with diverse directing groups
Xu, Jiabin,Mu, Xin,Chen, Pinhong,Ye, Jinxing,Liu, Guosheng
supporting information, p. 3942 - 3945 (2014/08/18)
The expansion of cross-coupling components in Cu-catalyzed C-X bond forming reactions have received much attention recently. A novel Cu-catalyzed trifluoromethylthiolation of aryl bromides and iodides with the assistance of versatile directing groups such as pyridyl, methyl ester, amide, imine and oxime was reported. CuBr was used as the catalyst, and 1,10-phenanthroline as the ligand. By changing the solvent from acetonitrile to DMF, the coupling process could even take place at room temperature.
Palladium-catalyzed trifluoromethylthiolation of aryl C-H bonds
Xu, Chunfa,Shen, Qilong
supporting information, p. 2046 - 2049 (2014/05/06)
A method for monotrifluoromethylthiolation of arenes via palladium-catalyzed directed C-H bond activation was described. The reaction was compatible with a variety of functional groups. Initial mechanistic studies disclosed that the turnover limiting step of the catalytic cycle did not involve C-H activation.
