811-68-7

Basic information

• Product Name: (Trifluoromethylthio) silver(I)
• Synonyms: (Trifluoromethylthio) silver(I);[(Trifluoromethyl)thio] silver(I);Silver(I)trifluoromethanethiolate
• CAS NO: 811-68-7
• Molecular Formula: CAgF₃S
• Molecular Weight: 209.94
• Mol File: 811-68-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility: Insoluble in water
• CAS DataBase Reference: (Trifluoromethylthio) silver(I)(CAS DataBase Reference)
• NIST Chemistry Reference: (Trifluoromethylthio) silver(I)(811-68-7)
• EPA Substance Registry System: (Trifluoromethylthio) silver(I)(811-68-7)

Safety Data

• Hazardous Substances Data: 811-68-7(Hazardous Substances Data)

Usage

General Description

(Trifluoromethylthio) silver(I) is a type of organosilver compound known for its roles in synthetic organic chemistry. The chemical formula for this compound is AgSCF3. It is often used as a reagent in the application of trifluoromethylthiolation, where it functions as a source of the trifluoromethylthio group. (Trifluoromethylthio) silver(I) is typically prepared via the reaction of silver(I) oxide and trifluoromethanethiol. Despite its usefulness, it is extremely sensitive to moisture and must be handled with care.

Upstream product

• 753-94-6 trifluoro methyl silyl sulfide 
• 506-64-9 silver(I) cyanide 
• 420-32-6 thiocarbonyl fluoride 
• 11113-87-4 silver fluoride 
• 330660-35-0 silver cyanide 
• 563-63-3 silver(I) acetate 
• 21259-75-6 mercury bis(trifluoromethanethiolate) 
• 75-15-0 carbon disulfide 
• 15223-20-8 1-methyl-4-{[(trifluoromethyl)sulfanyl]sulfonyl}benzene 
• 14104-20-2 silver tetrafluoroborate 
• 2926-29-6 Langlois reagent 
• 26042-63-7 silver(I) hexafluorophosphate 
• 2923-28-6 silver trifluoromethanesulfonate 
• 1493-15-8 trifluoromethylsulfide 

Downstream Products

• 2408-14-2 <3-Carboxy-benzyl>-trifluormethyl-sulfid 
• 351-60-0 benzyl trifluoromethyl sulfide 
• 29848-65-5 m-FC₆H₄CH(SCF₃)2 
• 24572-42-7 m-FC₆H₄C(SCF₃)3 
• 22230-28-0 2,4-dinitrophenyltrifluoromethyl sulfide 
• 421-16-9 methyl trifluoromethyl sulphide 
• 39566-17-1 1-(4-nitrophenyl)-2-((trifluoromethyl)thio)ethanone 
• 420-32-6 thiocarbonyl fluoride 
• 37771-97-4 N-phenylbenzenecarboximidoyl fluoride 
• 24628-90-8 tris(trifluoromethyl) benzeneorthotrithiobenzoate 
• 3872-23-9 Copper(I) trifluoromethanethiolate 
• 1567850-19-4 (S)-tert-butyl 3-phenyl-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 
• 1567850-21-8 (R)-tert-butyl 3-phenyl-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 
• 1567850-30-9 (S)-tert-butyl 3-p-tolyl-3-(trifluoromethanesulfenyl)-2-oxoindoline-1-carboxylate 

Relevant articles and documents

Ammonium Chloride-Mediated Trifluoromethylthiolation of p-Quinone Methides

Ammonium chloride-mediated trifluoromethylthiolation of p-quinone methides is reported using inexpensive and bench stable AgSCF3 as a nucleophilic trifluoromethylthiolating (-SCF3) reagent. This method is an efficient strategy for the construction of the benzylic C(sp3)-SCF3 bond to synthesize trifluoromethylthio-diarylmethane derivatives by 1,6-conjugate addition/aromatization under mild reaction conditions without any metal catalyst, oxidants, or additives. This is the first report of trifluoromethylthiolation of p-quinone methides. In addition, di-trifluoromethylthiolation of δ-chloro-p-quinone methide and scalability are demonstrated.

Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: A new protocol for potent trypanocidal quinones

We report a sequential C-H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry.