1584705-68-9Relevant articles and documents
Ligandless Nickel-Catalyzed Ortho-Selective Directed Trifluoromethylthiolation of Aryl Chlorides and Bromides Using AgSCF3
Nguyen, Tin,Chiu, Weiling,Wang, Xinying,Sattler, Madeleine O.,Love, Jennifer A.
, p. 5492 - 5495 (2016/11/17)
A mild protocol for Ni-catalyzed trifluoromethylthiolation of aryl chlorides and bromides is described herein. The method utilizes AgSCF3 as an easily accessible nucleophilic trifluoromethylthiolating reagent and does not require any ligands or additives. Ortho-selectivity is achieved using a variety of directing groups such as imines, pyridines, and oxazolines for 24 examples in up to 95% yield.