1584705-68-9

Basic information

• Product Name: 2-(2-methoxy-6-((trifluoromethyl)thio)phenyl)pyridine
• Synonyms: 2-(2-methoxy-6-((trifluoromethyl)thio)phenyl)pyridine
• CAS NO: 1584705-68-9
• Molecular Weight: 285.29
• Mol File: 1584705-68-9.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-methoxy-6-((trifluoromethyl)thio)phenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methoxy-6-((trifluoromethyl)thio)phenyl)pyridine(1584705-68-9)
• EPA Substance Registry System: 2-(2-methoxy-6-((trifluoromethyl)thio)phenyl)pyridine(1584705-68-9)

Safety Data

• Hazardous Substances Data: 1584705-68-9(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 385370-80-9 (2-chloro-6-methoxyphenyl)boronic acid 
• 1182190-94-8 2-(2-chloro-6-methoxyphenyl)pyridine 
• 811-68-7 silver(I) trifluoromethanethiolate 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 5957-89-1 2-(2-methoxy-phenyl)-pyridine 
• 183267-04-1 1-((trifluoromethyl)thio)pyrrolidine-2,5-dione 

Relevant articles and documents

Ligandless Nickel-Catalyzed Ortho-Selective Directed Trifluoromethylthiolation of Aryl Chlorides and Bromides Using AgSCF3

A mild protocol for Ni-catalyzed trifluoromethylthiolation of aryl chlorides and bromides is described herein. The method utilizes AgSCF3 as an easily accessible nucleophilic trifluoromethylthiolating reagent and does not require any ligands or additives. Ortho-selectivity is achieved using a variety of directing groups such as imines, pyridines, and oxazolines for 24 examples in up to 95% yield.

Palladium-catalyzed trifluoromethylthiolation of aryl C-H bonds

A method for monotrifluoromethylthiolation of arenes via palladium-catalyzed directed C-H bond activation was described. The reaction was compatible with a variety of functional groups. Initial mechanistic studies disclosed that the turnover limiting step of the catalytic cycle did not involve C-H activation.