158478-70-7

Basic information

• Product Name: N,N′-di-tert-butoxycarbonyl-N″-(cyclohexyl)guanidine
• Synonyms: N,N′-di-tert-butoxycarbonyl-N″-(cyclohexyl)guanidine
• CAS NO: 158478-70-7
• Molecular Weight: 341.451
• Mol File: 158478-70-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N,N′-di-tert-butoxycarbonyl-N″-(cyclohexyl)guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N′-di-tert-butoxycarbonyl-N″-(cyclohexyl)guanidine(158478-70-7)
• EPA Substance Registry System: N,N′-di-tert-butoxycarbonyl-N″-(cyclohexyl)guanidine(158478-70-7)

Safety Data

• Hazardous Substances Data: 158478-70-7(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 216584-22-4 N¹,N²,N³-tris(tert-butoxycarbonyl)guanidine 
• 145013-05-4 tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate 
• 332882-82-3 1,3-bis(t-butoxycarbonyl)guanidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 322474-21-5 N,N'-bis-Boc-S-methyl-isothiourea 
• 207857-15-6 1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 

Downstream Products

• 14948-83-5 N-cyclohexylquanidine 
• 2498-47-7 N-cyclohexylguanidine hydrochloride 

Relevant articles and documents

Iodine-catalyzed guanylation of amines with N, N ′-di-Boc-thiourea

Herein, we report that iodine-catalyzed guanylation of primary amines can be accomplished with N,N′-di-Boc-thiourea and TBHP to afford the corresponding guanidines in 40-99% yields. Oxidation of the HI byproduct by TBHP eliminates the need for an extra base to prevent the protonation of substrates and makes the reaction especially useful for both electronically and sterically deactivated primary anilines.

Synthetic method for preparing substituted guanidine by iodine-catalyzed thiourea desulfurization

The invention discloses a synthetic method for preparing substituted guanidine by iodine-catalyzed thiourea desulfurization, aiming at the fact that excessive heavy metals or oxidizing agents are required for synthesizing substituted guanidine in a traditional method. According to the method, starting from economical N,N'-di-tert-butyloxycarbonyl thiourea easy to obtain, a catalyst-involved thiourea desulfurization reaction is carried out to realize the preparation of guanidine containing different substituents. The synthetic method for preparing the substituted guanidine does not need additional alkali, has high atom economy and is mainly used for late modification of drug molecules and natural products.

ANTIMICROBIAL GUANIDINIUM AND THIOURONIUM FUNCTIONALIZED POLYMERS

Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.