15849-23-7Relevant academic research and scientific papers
New Friedel-Crafts strategy for preparing 3-acylindoles
Li, Lian-Hua,Niu, Zhi-Jie,Liang, Yong-Min
supporting information, p. 7792 - 7796 (2018/11/21)
A selective Friedel-Crafts acylation of indoles via an unusual cleavage of the amide C-N bond was achieved by triflic anhydride activation. This method offers rapid efficient access to high-biological-value 3-acylindoles, performs a series of scrupulous mechanistic studies and offers a strong courage that amide synthons can form new C-C bonds under transition-metal-free conditions.
Syntheses of 3-acylindoles via the alkylation of the dianion of 3-acetylindole
Byers, Jeffrey H.,Zhang, Yong
, p. 1293 - 1297 (2007/10/03)
The dianion of 3-acetylindole can be generated upon sequential treatment with NaH and n-BuLi. This dianion can be C-alkylated at the acetyl methyl group with high regioselectivity, leading to efficient syntheses of 3-acylindoles. Addition of excess electrophile leads to a dialkylated product.
