158497-86-0

Upstream product

• 158497-84-8 (2R,3S,E)-2,6-bis(tetrahydropyranyloxy)-4-hexen-1,3-diol 1,3-diacetate 
• 38081-33-3 (2R,3S,E)-4-hexen-1,2,3,6-tetraol 1,3-diacetate 
• 29581-05-3 (2E,4S,5R)-4,6-diacetoxy-5-hydroxy-2(E)-hexenal 
• 98-59-9 p-toluenesulfonyl chloride 
• 158497-85-9 (2R,3S,E)-2,6-bis(tetrahydropyranyloxy)-4-hexen-1,3-diol 

Downstream Products

• 158497-87-1 (2R,3S,E)-2,3,6-trihydroxy-4-hexenyl p-toluene-sulfonate 
• 134659-97-5 (1S,2S,E)-1-methyl-2,5-bis(tetrahydropyranyloxy)-3-pentenyl benzoate 

Relevant academic research and scientific papers

Total Synthesis of Natural (+)-Phomopsolide B, an Antifeedant against Elm Bark Beetle

The total synthesis of natural (+)-phomopsolid B (2) is described.A 5,6-dihydro-2H-pyran-2-one framework was constructed by coupling chiral aldehyde 4 and 4-oxygenated enaminoester 5.The resulting 5,6-dihydro-4-pyrrolidyl-2H-pyran-2-one (3) was converted to natural (+)-phomopsolide B (2) in several steps.