15850-20-1

Usage

Uses

Used in Organic Synthesis:
4-nitro-N-(1,3-thiazol-2-yl)benzamide is used as a building block in organic synthesis for the development of a range of biologically active compounds. Its unique structure allows for the creation of diverse chemical entities with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-nitro-N-(1,3-thiazol-2-yl)benzamide is employed as a key component in the synthesis of pharmaceuticals. Its incorporation into drug molecules can contribute to the discovery of new therapeutic agents.
Used in Antifungal Applications:
4-nitro-N-(1,3-thiazol-2-yl)benzamide is used as an antifungal agent due to its potential biological activity against certain fungal pathogens. Its ability to inhibit fungal growth makes it a candidate for further research and development in antifungal therapies.
Used in Antibacterial Applications:
4-nitro-N-(1,3-thiazol-2-yl)benzamide is also utilized as an antibacterial agent, showing promise in combating bacterial infections. Its potential to inhibit bacterial growth has garnered interest for its use in the development of new antimicrobial treatments.
Used in Anti-cancer Applications:
4-nitro-N-(1,3-thiazol-2-yl)benzamide is used as an anti-cancer agent, as it has been studied for its ability to inhibit specific enzymes and cell signaling pathways. This property makes it a candidate for further exploration in cancer research and the development of novel cancer therapies.
Overall, 4-nitro-N-(1,3-thiazol-2-yl)benzamide is a multifaceted compound with potential applications in various scientific and medical fields, including organic synthesis, medicinal chemistry, antifungal and antibacterial treatments, and anti-cancer research.

Upstream product

• 96-50-4 2-thiazolylamine 
• 1429-05-6 phenyl 4-nitrobenzoate 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 247225-81-6 4-amino-N-thiazol-2-yl-benzamide 

Relevant academic research and scientific papers

Solvent-Free Synthesis, ADME Prediction, and Evaluation of Antibacterial Activity of Novel Sulfonamide Derivatives

A series of novel sulfonamides containing a 2-amino-1,3-thiazole fragment have been synthesized using a simple and efficient method under solvent-free conditions. The obtained N-(4-sulfamoyl-1,3-thiazol-2-yl)-4-nitrobenzamides were evaluated for their ant

Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)- 3,5-difluorobenzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A phosphonooxymethylene prodrug of a potent and selective hA2A receptor antagonist

The discovery and structure-activity relationship of a series of hA 2A receptor antagonists is described. Compound 28 was selected from the series as a potent and selective compound and was shown to be efficacious in an in vivo model of Parkinson's disease. It had acceptableADME properties; however, the low intrinsic solubility of this compound was limiting for its developability, because the oral bioavailability from dosing in suspension was significantly lower than the oral bioavailability from solution dosage. As a consequence, prodrugs of 28 were prepared with dramatically increased aqueous solubility. The prodrugs efficiently delivered 28 into systemic circulation, with no detectable levels of prodrug in plasma samples. From this investigation, we selected 32 (Lu AA47070), a phosphonooxymethylene prodrug of 28, as a drug candidate.

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype- and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, compounds based on the benzimidazole pharmacophore, but also hydroxyquinoline and picolinic acid derivatives. Our data indicates that a significant degree of selectivity can be attained with metal-dependent MetAP inhibitors.

PRO-DRUGS OF N-THIAZOL-2YL-BENZAMIDE DERIVATIVES

The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are pro-drugs of A2A-receptor ligands with improved aqueous solubility, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.

N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES

The invention relates to N-thiazol-2-yl-benzamide derivatives of the formula I in the description wherein the variables are as defined in the claims. The compounds are A2A-receptor ligands, such as antagonists, agonists, reverse agonists or partial agonists, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.

Ring-opened analogs of indomethacin affecting human neutrophil functions

A series of ring-opened analogs of indomethacin was synthesized and tested in vitro (at concentrations ranging from 10-9 to 10-5 mol/1) on human neutrophil functions. Two compounds lacking the carboxylic group were subjected to the s