1585168-77-9Relevant academic research and scientific papers
Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase
Urbaniak, Michael D.,Capes, Amy S.,Crossman, Arthur,O'Neill, Sandra,Thompson, Stephen,Gilbert, Ian H.,Ferguson, Michael A.J.
, p. 54 - 58 (2014/03/21)
The zinc-metalloenzyme GlcNAc-PI de-N-acetylase is essential for the biosynthesis of mature GPI anchors and has been genetically validated in the bloodstream form of Trypanosoma brucei, which causes African sleeping sickness. We screened a focused library
