1585185-79-0Relevant academic research and scientific papers
An organocatalytic method for constructing pyrroles: Via the cycloisomerisation of Z -1-iodo-4- N -methylbenzenesulfonyl-1,6-enynes
Meng, Long,Chi, Xiaochen,Sun, Xi,Cao, Chengqiang,Ai, Bing,Liu, Qing,Zhao, Pingping,Zhao, Zengdian,Dong, Yunhui,Liu, Hui
, p. 7669 - 7673 (2019/08/30)
A new cycloisomerisation of Z-1-iodo-4-N-methylbenzenesulfonyl-1,6-enynes to functionalized pyrroles was realized in the presence of an organomolecule (4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine) and KOtBu. The transformations were performed efficiently to produce different kinds of functionalized pyrroles within 10 min. This is the first example of an organomolecule promoted methodology with vinyl iodides from a non-aromatic system to an aromatic system, which offers an excellent option toward establishing a new horizon for cross-coupling reactions of vinyl halides. Preliminary mechanistic studies were performed and a crude radical pathway was proposed.
Palladium-catalyzed cyclization of vinyl iodide-tethered allensulfonamide
Xie, Zheng,Wu, Pan,Cai, Liangzhen,Tong, Xiaofeng
supporting information, p. 2160 - 2162 (2014/04/03)
This Letter describes a palladium-catalyzed cyclization of vinyl iodide-tethered allensulfonamide in the presence of alkylol, which provides a facile access to 2-alkoxy-3-methylene-tetrahydropyridine. The asymmetric version of this reaction has also been preliminarily realized with up to 81% enantioselectivity when chiral bisphosphine ligands were used.
