158555-49-8

Basic information

• Product Name: (4-Bromomethyl-2,6-dimethoxy-phenoxy)-tert-butyl-dimethyl-silane
• Synonyms: (4-Bromomethyl-2,6-dimethoxy-phenoxy)-tert-butyl-dimethyl-silane
• CAS NO: 158555-49-8
• Molecular Weight: 361.351
• Mol File: 158555-49-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4-Bromomethyl-2,6-dimethoxy-phenoxy)-tert-butyl-dimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Bromomethyl-2,6-dimethoxy-phenoxy)-tert-butyl-dimethyl-silane(158555-49-8)
• EPA Substance Registry System: (4-Bromomethyl-2,6-dimethoxy-phenoxy)-tert-butyl-dimethyl-silane(158555-49-8)

Safety Data

• Hazardous Substances Data: 158555-49-8(Hazardous Substances Data)

Upstream product

• 141327-85-7 4-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 106852-80-6 4-(t-butyldimethylsilyloxy)-3,5-dimethoxybenzaldehyde 
• 134-96-3 syringic aldehyde 

Downstream Products

• 158555-91-0 1-<(tert-Butyldimethylsilyl)oxy>-2,6-dimethoxy-4-<4-butyl>benzene 
• 158555-61-4 2,6-Dimethoxy-4-<4-butylidene>-2,5-cyclohexadien-1-one 
• 158555-52-3 2,6-Dimethoxy-4-<4-butyl>phenol 
• 158555-66-9 (+/-)-2-<(3,5-Dimethoxy-4-oxo)-2,5-cyclohexadienylidene>spiroindole> 
• 158555-51-2 2,6-Dimethoxy-4-<4-(indol-3-yl)butyl>phenol 

Relevant articles and documents

Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: A resveratrol structural modification

As an extension of our earlier structure/activity investigation of resveratrol (1a) cancer cell growth inhibitory activity compared to the structurally related stilbene combretastatin series (e.g., 2a), an efficient synthesis of E-stilstatin 3 (3a) and its phosphate prodrug 3b was completed. The trans-stilbene 3a was obtained using a convergent synthesis employing a Wittig reaction with phosphonium bromide 9 as the key reaction step. Deprotection of the Z-silyl ether 13 gave E-stilstatin 3 (3a) as the exclusive product. The structure and stereochemistry of 3a was confirmed by X-ray crystal structure determination.