158602-32-5

Basic information

• Product Name: ETHYL 2-(1-BENZHYDRYLAZETIDIN-3-YLIDENE) ACETATE
• Synonyms: ETHYL 2-(1-BENZHYDRYLAZETIDIN-3-YLIDENE) ACETATE;Acetic acid, 2-[1-(diphenylMethyl)-3-azetidinylidene]-, ethyl ester
• CAS NO: 158602-32-5
• Molecular Formula: C20H21NO2
• Molecular Weight: 307.4
• Mol File: 158602-32-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 415.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.191±0.06 g/cm3(Predicted)
• PKA: 5.60±0.20(Predicted)
• CAS DataBase Reference: ETHYL 2-(1-BENZHYDRYLAZETIDIN-3-YLIDENE) ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(1-BENZHYDRYLAZETIDIN-3-YLIDENE) ACETATE(158602-32-5)
• EPA Substance Registry System: ETHYL 2-(1-BENZHYDRYLAZETIDIN-3-YLIDENE) ACETATE(158602-32-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 158602-32-5(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(1-BENZHYDRYLAZETIDIN-3-YLIDENE) ACETATE is a chemical compound that is derived from azetidine, a four-membered ring with nitrogen as the heteroatom, and ethyl acetate. It is a yellow liquid with a molecular formula C16H19NO2 and a molecular weight of 257.33 g/mol. ETHYL 2-(1-BENZHYDRYLAZETIDIN-3-YLIDENE) ACETATE has potential applications in the field of organic synthesis and pharmaceuticals due to its unique structural properties. Additionally, it may have uses in the development of new drugs and as a building block for the synthesis of other complex organic molecules. Further research into its properties and potential applications is ongoing.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 40320-60-3 N-benzhydryl 3-azetidinone 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 942307-65-5 1-Benzhydryl-3-(2-methoxyethyl)azetidine 
• 712317-32-3 ethyl 2-(3-azetidinyl)acetate hydrochloride 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives against Gram-Negative Multidrug-Resistant Pathogens

Due to the poor permeability across Gram-negative bacterial membranes and the troublesome bacterial efflux mechanism, only a few GyrB/ParE inhibitors with potent activity against Gram-negative pathogens have been reported. Among them, pyrimido[4,5-b]indol

Preparation method of tert-butyl-5-(hydroxymethyl)-7-oxa-2-azaspiro[3.5]nonane-2-formate

The invention relates to a preparation method of tert-butyl-5-(hydroxymethyl)-7-oxa-2-azaspiro[3.5]nonane-2-formate, and mainly solves the technical problem that no proper industrial synthesis methodexists at present. The product is synthesized by six steps, and the preparation method comprises the steps: a first step, a compound 1 is subjected to Swern oxidation reaction to generate a compound 2; a second step, a compound 3 is obtained through a Horner-Wadsworth-Emmons reaction; a third step, a compound 4 is obtained through Michael addition; a fourth step, a compound 5 is obtained through reduction of the compound 4 with lithium tetrahydroaluminum; a fifth step, the compound 5 is dehydrated and retained with a ring to obtain a compound 6 under the action of sodium hydrogen; and a sixthstep, hydrogenation is preformed to remove a protective group, and then a protective group is added to obtain the target compound 7. The obtained compound is a useful intermediate or product for synthesis of many drugs.

AZETIDINYL QUINOLONES AS ANTIBACTERIAL AGENTS

Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compoun