712317-32-3

Basic information

• Product Name: 3-AZETIDINEACETIC ACID ETHYL ESTER HYDROCHLORIDE
• Synonyms: 3-AZETIDINEACETIC ACID ETHYL ESTER HYDROCHLORIDE;3-Azetidineacetic acid ethyl ester HCl
• CAS NO: 712317-32-3
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.646
• Mol File: 712317-32-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-AZETIDINEACETIC ACID ETHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AZETIDINEACETIC ACID ETHYL ESTER HYDROCHLORIDE(712317-32-3)
• EPA Substance Registry System: 3-AZETIDINEACETIC ACID ETHYL ESTER HYDROCHLORIDE(712317-32-3)

Safety Data

• Hazardous Substances Data: 712317-32-3(Hazardous Substances Data)

Upstream product

• 158602-32-5 ethyl 2-[1-(diphenylmethyl)azetidin-3-ylidene]acetate 
• 183062-96-6 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid 
• 158602-35-8 tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate 

Downstream Products

• 937055-20-4 ethyl 2-(1-(3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl)-3-azetidinyl)acetate 
• 1332331-73-3 5-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4-[4-(1H-indazol-6-yl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332331-78-8 4-[4-(1-benzofuran-5-yl)phenyl]-5-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 937055-21-5 2-(1-(3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl)-3-azetidinyl)acetic acid 

Relevant articles and documents

Discovery of novel tricyclic compounds as squalene synthase inhibitors

In the present article, we have reported the design, synthesis, and identification of highly potent benzhydrol derivatives as squalene synthase inhibitors (compound 1). Unfortunately, the in vivo efficacies of the compounds were not enough for acquiring the clinical candidate. We continued our investigation to obtain a more in vivo efficacious template than the benzhydrol template. In our effort, we focused on a benzoxazepine ring and designed a new tricyclic scaffold by the incorporation of heterocycle into it. Prepared pyrrolobenzoxazepine derivatives showed further efficient in vitro and in vivo activities.

TRICYCLIC COMPOUND

The present invention relates to tricyclic compounds each represented by the following formula (I): (wherein, R1, R2, R2', R3, R4, X, Y and Z have the same meanings as defined in the specification); and a drug containing the compound. Since the compounds according to the present invention exhibit an excellent squalene synthetase inhibitory effect and cholesterol synthesis inhibitory effect so that they are useful as a drug such as preventive and/or remedy for diseases in mammals including humans such as hyperlipemia, e.g., hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia and/or arteriosclerosis.