15861-40-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole-7-carboxylic acid, 2,3-dihydrois used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique chemical properties allow it to contribute to the development of new medications with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 1H-Indole-7-carboxylic acid, 2,3-dihydrois utilized as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its chemical structure enables it to be a part of compounds that can effectively control, repel, or kill pests and weeds, thus contributing to agricultural productivity and crop protection.
Used in Organic Chemistry Research:
1H-Indole-7-carboxylic acid, 2,3-dihydrois used as a building block in the production of various other organic compounds. Its versatile structure allows researchers and chemists to explore its potential in creating new organic molecules with unique properties and applications, further expanding the scope of organic chemistry.

Upstream product

• 34851-16-6 4,5-dihydropyrrolo[3,2,1-hi]indole-1,2-dione 
• 75934-13-3 2-{2-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-ethyl}-isoindole-1,3-dione 
• 31456-98-1 methyl 3-allyl-salicylate 
• 119-36-8 methyl salicylate 
• 1670-83-3 1H-Indole-7-carboxylic acid 
• 115661-82-0 7-cyanoindoline 
• 115992-15-9 S-methyl 2,3-dihydro-1H-indole-7-carbothioate 
• 75934-11-1 2-<2-Methoxy-3-(2-hydroxyethyl)phenyl>-4,4-dimethyl-2-oxazoline 
• 75934-14-4 2-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-ethylamine 
• 75934-12-2 2-[3-(2-Methanesulfonyl-ethyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole 
• 75934-03-1 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline 
• 75934-02-0 2-(3-allyl-2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole 
• 75934-00-8 2-Allyl-6-(carbomethoxy)anisole 
• 75934-01-9 2-Methoxy-3-allylbenzoic Acid 

Downstream Products

• 1670-83-3 1H-Indole-7-carboxylic acid 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed selective C-H cyanation of indolines and indoles with an easily accessible cyano source

The rhodium-catalyzed selective cyanation of C-H bonds of indolines and indoles with N-cyano-N-phenyl-para-methylbenzenesulfonamide is described. This protocol offers a facile access to C-7 cyanated indolines and C-2 cyanated indoles with high site selectivity and excellent functional group tolerance.

Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions

Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermediate. This new type of catalyst showed up to 15-fold rate enhancement over the traditional anilinecatalyzed reaction at neutral conditions. The identified indoline catalyst was successfully applied in hydrogel formation.

INSECTICIDAL AMIDES WITH NITROGEN-CONTAINING BENZO-FUSED BICYCLIC RING SYSTEMS

Disclosed are compounds of Formula I and compounds of Formula II (including all geometric and stereoisomers), N-oxides thereof and salts thereof, certain compositions comprising the compounds of Formula I and/or the compounds of Formula II and certain use

Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents

Heterocyclic analogues of 1192U90, 2-amino-N-(4-(4-(1,2-benzisothiazol- 3-yl)-1-piperazinyl)-butyl)benzamide hydrochloride (1), were prepared and evaluated as potential antipsychotic agents. These analogues were evaluated in vitro for their binding to the dopamine D2, serotonin 5-HT2, and serotonin 5-HT(1a) receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. Nine different types of heterocyclic carboxamides were studied in this investigation (i.e., pyridine- , thiophene-, benzothiophene-, quinoline-, 1,2,3,4-tetrahydroquinoline-, 2,3- dihydroindole-, indole-, benzimidazole-, and indazolecarbox-amides). Two derivatives exhibited potent in vivo activities comparable to 1: 3-amino-N- (4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2-pyridinecarboxamide (16) and 3-amino-N-(4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2- thiophenecarboxamide (29). Furthermore, these derivatives were found to be much less active in behavioral models predictive of extrapyramidal side effects than in the mouse climbing assay, which predicts antipsychotic activity. Carboxamides 16 and 29 were selected for further evaluation as potential backup compounds to 1.

Tricyclic compounds

Tricyclo benzodiazepines are cholecystokinin antagonists.

7-(α-Acetylbenzyl)indoline

The preparation of compounds of the formula SPC1 Wherein R is selected from the group consisting of hydrogen and chlorine is described. The compounds are useful as chemical intermediates and as anti-inflammatory agents.