1670-83-3

Usage

Uses

Used in Organic Synthesis:
1H-Indole-7-carboxylic acid is used as a building block in organic synthesis for the creation of various complex organic molecules. Its versatile chemical structure allows it to be a key component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Industry:
1H-Indole-7-carboxylic acid is used as an intermediate in the development of pharmaceuticals. Its unique structure makes it a valuable component in the synthesis of drugs targeting specific biological pathways and receptors.
Used in Agrochemicals:
1H-Indole-7-carboxylic acid is used as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties enable it to be incorporated into molecules that can effectively control, repel, or kill unwanted organisms in agricultural settings.
Used in Dye Industry:
1H-Indole-7-carboxylic acid is used as a starting material in the synthesis of dyes and pigments. Its indole ring structure provides a foundation for creating a variety of colored compounds used in various industries, including textiles, plastics, and printing.

InChI:InChI=1/C9H7NO2/c11-9(12)7-3-1-2-6-4-5-10-8(6)7/h1-5,10H,(H,11,12)/p-1

Upstream product

• 96631-87-7 1H-indole-7-carbonitrile 
• 68109-89-7 β-(dimethylamino)-3-carbomethoxy-2-nitrostyrene 
• 15861-40-2 2,3-dihydro-1H-indole-7-carboxylic acid 
• 51417-51-7 7-bromo-1H-indole 
• 201230-82-2 carbon monoxide 
• 496-15-1 1-indoline 
• 28899-75-4 7-Chloro-1H-indole-2-carboxylic acid 
• 77158-85-1 (3-chloro-2-nitro-phenyl)-pyruvic acid 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 34851-16-6 4,5-dihydropyrrolo[3,2,1-hi]indole-1,2-dione 
• 34851-15-5 2-(2,3-dihydro-1H-indol-1-yl)glyoxyloyl chloride 

Downstream Products

• 289724-90-9 1-(7-indolecarbonyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine 
• 156905-27-0 N-[2-(dimethylamino)ethyl]-1H-indole-7-carboxamide 
• 934486-77-8 C₁₅H₁₁ClN₂O 
• 1221403-26-4 C₂₆H₂₃N₃O₂ 
• 1239447-56-3 N-(2-(3-benzoylphenyl)propyl)-1H-indole-7-carboxamide 
• 93247-78-0 methyl 1H-indole-7-carboxylate 
• 1074-88-0 1H-indole-7-carbaldehyde 
• 205873-58-1 ethyl 1H-indole-7-carboxylate 
• 15861-40-2 2,3-dihydro-1H-indole-7-carboxylic acid 
• 104019-20-7 1-(1H-indol-7-yl)ethan-1-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Carbonylation of Haloindoles: No Need for Protecting Groups

(Equation presented) For the first time, palladium-catalyzed carbonylations of unprotected bromoindoles have been performed successfully with different N- and 0-nucleophiles. Various indole carboxylic acid derivatives are accessible in excellent yield. For example, aminocarbonylation of 4-, 5-, 6-, or 7-bromoindole with arylethylpiperazines provides a direct one-step synthesis for CNS active amphetamine derivatives.

NEW SYNTHESIS OF INDOLE-7-CARBOXYLIC ACID

A new preparative method for synthesis of indole-7-carboxylic acid has been developed, consisting in reductive cyclization of β-(dimethylamino)-3-carbomethoxy-2-nitrostyrene by the action of iron in acetic acid.

Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents

Heterocyclic analogues of 1192U90, 2-amino-N-(4-(4-(1,2-benzisothiazol- 3-yl)-1-piperazinyl)-butyl)benzamide hydrochloride (1), were prepared and evaluated as potential antipsychotic agents. These analogues were evaluated in vitro for their binding to the dopamine D2, serotonin 5-HT2, and serotonin 5-HT(1a) receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. Nine different types of heterocyclic carboxamides were studied in this investigation (i.e., pyridine- , thiophene-, benzothiophene-, quinoline-, 1,2,3,4-tetrahydroquinoline-, 2,3- dihydroindole-, indole-, benzimidazole-, and indazolecarbox-amides). Two derivatives exhibited potent in vivo activities comparable to 1: 3-amino-N- (4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2-pyridinecarboxamide (16) and 3-amino-N-(4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2- thiophenecarboxamide (29). Furthermore, these derivatives were found to be much less active in behavioral models predictive of extrapyramidal side effects than in the mouse climbing assay, which predicts antipsychotic activity. Carboxamides 16 and 29 were selected for further evaluation as potential backup compounds to 1.