158612-41-0

Upstream product

• 138279-20-6 (S)-(+)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid 
• 138279-12-6 (S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 158612-43-2 (R)-methyl pivaloyloxymethyl 2-bromomethyl-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 

Downstream Products

• 158612-42-1 (R)-methyl pivaloyloxymethyl 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 109545-30-4 (+)-Nilvadipine 

Relevant academic research and scientific papers

Lipase-catalyzed asymmetric hydrolysis and regioselective bromination of 1,4-dihydropyridine. Synthesis of (R)-(+)-nilvadipine

Homochiral (R)-(+)-nilvadipine was synthesized from a prochiral substrate using lipase-catalyzed asymmetric hydrolysis and subsequent regioselective bromination as key steps.

Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives

Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot