Lipase-catalyzed asymmetric hydrolysis and regioselective bromination of 1,4-dihydropyridine. Synthesis of (R)-(+)-nilvadipine

DOI: 10.1016/0957-4166(94)80108-8

Source and publish data:

Tetrahedron Asymmetry p. 1447 - 1450 (1994)

Update date:2022-08-04

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Authors:

Ebiike Ebiike

Achiwa Achiwa

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Article abstract of DOI:10.1016/0957-4166(94)80108-8

Homochiral (R)-(+)-nilvadipine was synthesized from a prochiral substrate using lipase-catalyzed asymmetric hydrolysis and subsequent regioselective bromination as key steps.

Full text of DOI:10.1016/0957-4166(94)80108-8

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