Lipase-catalyzed asymmetric hydrolysis and regioselective bromination of 1,4-dihydropyridine. Synthesis of (R)-(+)-nilvadipine

Article abstract of DOI:10.1016/0957-4166(94)80108-8

Homochiral (R)-(+)-nilvadipine was synthesized from a prochiral substrate using lipase-catalyzed asymmetric hydrolysis and subsequent regioselective bromination as key steps.