15862-33-6

Usage

Uses

Used in Organic Synthesis:
3-Bromo-2-hydroxy-5-nitropyridine is used as a building block in organic synthesis for the production of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and reactivity allow for the formation of carbon-carbon and carbon-nitrogen bonds, facilitating the creation of complex molecules with potential applications in various industries.
Used in Chemical Reactions:
3-Bromo-2-hydroxy-5-nitropyridine is used as a reagent in chemical reactions, particularly for the formation of carbon-carbon and carbon-nitrogen bonds. Its presence in these reactions can enhance the synthesis process and improve the yield of desired products, making it a valuable component in the development of new chemical compounds.
Used in Research Fields:
Due to its unique structure and reactivity, 3-Bromo-2-hydroxy-5-nitropyridine has applications in various research fields. It can be utilized in the study of chemical reactions, the development of new synthetic methods, and the exploration of novel compounds with potential applications in medicine, agriculture, and other industries.

InChI:InChI=1/C5H3BrN2O3/c6-4-1-3(8(10)11)2-7-5(4)9/h1-2H,(H,7,9)

Upstream product

• 5418-51-9 5-nitro-2-hydroxypyridine 
• 1868-58-2 3-bromo-2-fluoro-5-nitropyridine 

Downstream Products

• 5470-17-7 3-bromo-2-chloro-5-nitropyridine 
• 15862-36-9 2,3-dibromo-5-nitropyridine 
• 206759-33-3 2-isopropoxy-3-bromo-5-nitropyridine 
• 206758-92-1 methyl[3(S),5(R),6(S),7(S)]-6-(4-fluorophenyl)-3-[2-isopropoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-pyridin-3-yl]-1-oxa-spiro[4.4]nonane-7-carboxylate 
• 232944-46-6 methyl[5(R),6(S),7(S)]-6-(4-fluorophenyl)-3-[2-isopropoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-pyridin-3-yl]-1-oxa-spiro[4.4]non-3-ene-7-carboxylate 
• 1119090-69-5 ethyl 2-(6-(3-methoxyphenyl)-5-phenylpyridin-3-ylamino)-5-methylbenzoate 
• 1119085-69-6 2-(6-(3-methoxyphenyl)-5-phenylpyridin-3-ylamino)-5-methylbenzoic acid 
• 1119088-65-1 6-(3-methoxyphenyl)-5-phenylpyridin-3-amine 
• 1119088-71-9 2-(3-methoxyphenyl)-5-nitro-3-phenylpyridine 
• 1119088-68-4 3-bromo-2-(3-methoxyphenyl)-5-nitropyridine 
• 186593-43-1 5-amino-3-bromo-2-methylpyridine 
• 186593-42-0 3-bromo-2-methyl-5-nitropyridine 
• 15862-50-7 3-bromo-2-methoxy-5-nitropyridine 
• 130115-85-4 5-bromo-6-chloropyridin-3-ol 

Relevant academic research and scientific papers

One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation.

Compounds for inflammation and immune-related uses

The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present disclosure is directed to compounds of formula (Ie) and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, m, n, X1, X2, X3 and X4 are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

A 2-amino-thiazole compounds (by machine translation)

The present invention relates to the technical field of pharmaceutical chemistry, particularly relates to a 2-amino thiazole compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)

DYE COMPOSITION COMPRISING A 1,2,3,4-TETRAHYDROPYRIDO[2,3-B]PYRAZIN-7-AMINE COMPOUND

The invention relates to a 1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-amine compound of formula (I) below, addition salts thereof, optical isomers, geometrical isomers and tautomersthereof and/or solvates thereof: in which: ?R2, R3, R4, R5, and R7 independently represent: a hydrogen or halogen atom; a C1-C4 alkyl radical; a C1-C4 hydroxyalkyl radical; a carboxyl radical; a (C1-C4)alkoxycarbonyl radical; ? R1 and R6, which may be identical or different, represent: hydrogen atom; C1-C10 and preferably Ci-C6 alkyl radical, - optionally interrupted with one or more heteroatoms chosen from O and S or with one or more groups -NR and/or - optionally terminating with at least one group -NX1X2 or at least one group -OX3, ? X1 and X2 independently denote - a hydrogen atom, a linear C1-C6 alkyl radical, a branched C3-C6 alkyl radical, a linear C1-C6 hydroxyalkyl radical or a branched C3-C6 hydroxyalkyl radical, X1 and X2 may form, with the nitrogen atom that bears them, a saturated or unsaturated 5- to 8-membered heterocycle, in which one of the ring members may be a heteroatom chosen from O, S and N; the said heterocycle possibly being substituted with one or more linear or branched C1-C4 alkyl or C1-C4 hydroxyalkyl radicals, ? X3 denotes - a hydrogen atom - a linear C1-C4 or branched C3-C4 alkyl radical, and ? R denotes - a hydrogen atom - a linear C1-C4 alkyl radical.

AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS

New azabiphenylaminobenzoic acid derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH)

Amino substituted aryloxybenzylpiperidine derivatives

This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention.

Arylthiobenzylpiperidine derivatives

This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.

Amino substituted aryloxybenzylpiperidine derivatives

This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.

Arylthiobenzylpiperidine derivatives

This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention.