15862-46-1

Usage

Uses

Used in Pharmaceutical Industry:
3-(Acetylamino)-5-bromopyridine is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the development of new drugs, potentially leading to the creation of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(Acetylamino)-5-bromopyridine is utilized as an intermediate in the production of agrochemicals. Its properties make it suitable for the synthesis of compounds that can be used in the development of pesticides, herbicides, and other agricultural chemicals to improve crop protection and yield.
Used in Research and Development:
3-(Acetylamino)-5-bromopyridine is employed as a research compound for exploring its potential applications in various fields. Its unique chemical properties make it a valuable tool for scientists to study and develop new methodologies, reactions, and applications in organic chemistry and related disciplines.

Upstream product

• 13535-01-8 3-amino-5-bromopyridine 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 625-92-3 3,5-dibromopyridine 

Downstream Products

• 1201646-60-7 N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide 
• 1201646-58-3 N-(5-(3-benzyl-1-bromo-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide 
• 1201646-59-4 N-(5-(2-benzyl-2H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide 
• 1201646-57-2 N-(5-(3-benzyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide 
• 1201645-46-6 N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide 

Relevant academic research and scientific papers

Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket

Mixed lineage leukemia (MLL) gene rearrangement induces leukemic transformation by ectopic recruitment of disruptor of telomeric silencing 1-like protein (DOT1L), a lysine histone methyltransferase, leading to local hypermethylation of H3K79 and misexpression of genes (including HoxA), which drive the leukemic phenotype. A weak fragment-based screening hit identified by SPR was cocrystallized with DOT1L and optimized using structure-based ligand optimization to yield compound 8 (IC50 = 14 nM). This series of inhibitors is structurally not related to cofactor SAM and is not interacting within the SAM binding pocket but induces a pocket adjacent to the SAM binding site.

CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I); where A1, A2, G, R1, R2, R3, R4, and W are described herein.

A universal acetyl-aminopyridine boric acid frequency alcohol ester preparation method

The invention belongs to the field of organic compound synthesis and provides a preparation method of commonly used acetamidopyridine boronic acid pinacol ester. The preparation method comprises the following steps: 1. with halogenated aminopyridine as a starting material, reacting with acetic anhydride in dichloromethane to obtain halogenated acetamidopyridine; and 2. with dioxane as a solvent, mixing the halogenated acetamidopyridine, potassium acetate and bis(pinacolato)diboron under the protection of nitrogen and adding a catalyst ferrocene palladium chloride to react at 60-100 DEG C for 18-24 hours, thus generating the acetamidopyridine boronic acid pinacol ester. The raw materials are convenient to directly purchase from the markets. The preparation method is simple, is convenient to operate, is high in yield and is convenient for industrial production.

FUROPYRIDINES AS BROMODOMAIN INHIBITORS

The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

Silica-supported boric acid catalyzed synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, esters and amides

Silica-supported boric acid (H3BO3-SiO2) has been established as a green, efficient and recyclable catalyst for the synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, and acetylation of alcohols, phenols, amines and thiols under solvent free conditions. The main features of the present method include clean reaction, mild conditions, low loading of environment friendly catalyst and easy workup procedure. The catalyst can be recycled at least five times without any significant loss in activity.

ALDOSTERONE SYNTHASE INHIBITORS

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2. R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.